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Neocentromeres

  • Owen J. Marshall
  • K.H Andy Choo
Chapter

Introduction

Almost all eukaryotic centromeres are marked by their accumulation of repetitive DNA. Such repeats are specific to the organism, and indicate some form of sequence sharing between centromeres. Generally, the pattern at the core of the centromere is of a tandem repeat unit, organised into higher order repeats. In humans, the repeat has been termed alpha-satellite (or alphoid) DNA and a consensus sequence exists between centromeres (Choo et al. 1991). As such, the concept of a relationship between DNA sequence and centromere formation was compelling.

All this changed, however, with the discovery in 1993 of an ectopic centromere, or ‘neocentromere’, formed on a marker chromosome without any alpha-satellite DNA (Voullaire et al. 1993). The centromere on this marker chromosome, designated mardel (10), was shown to have formed at 10q25––a euchromatic region of a chromosome arm that had not undergone any rearrangement or sequence change (du Sart et al. 1997; Lo et al. 2001a)....

Keywords

Bacterial Artificial Chromosome Marker Chromosome Ring Chromosome Human Artificial Chromosome Centromeric Chromatin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank E. Northrop and M. Pertile for stimulating discussions and critical comments on the manuscript. This work was supported by the National Health and Medical Research Council of Australia and the National Institutes of Health.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Laboratory of Chromosome and Chromatin ResearchMurdoch Children’s Research Institute, Royal Children’s HospitalParkville Victoria 3052Australia

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