The Basics of Chromosome Segregation

  • Mitsuhiro Yanagida

Scope of this Chapter

During cell division, chromosomes carrying thousands of genes are correctly transmitted to daughter cells via a motile apparatus named the mitotic spindle (a schematic outline of the cell (division) cycle is shown in Fig. 2.1 ). In postreplicative (post S phase) cells, chromosomes comprise duplicated sister chromatids. In the cell cycle stage called mitotic metaphase, all sister chromatid pairs are aligned and bi-oriented to the spindle apparatus. In anaphase, all sister chromatids separate in concert and segregate oppositely along the anaphase spindle (towards the spindle poles/centrosomes) into the two daughter cells (Fig. 2.2 ). The once-in-a-cell-cycle occurrence of the chromosome-segregation process suggests that this event should be studied with respect to cell cycle control (reviewed in Morgan 2006).


Sister Chromatid Chromosome Segregation Spindle Pole Spindle Checkpoint Mitotic Checkpoint 
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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.CREST Research Program, Japan Science and Technology Corporation (JST), Graduate School of BiostudiesKyoto University, Japan and Initial Research Program (IRP), Okinawa Institute of Science and Technology (OIST) Promotion CorporationUruma 904-2234Japan

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