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The Kinetochore as Target for Cancer Drug Development

  • Song-Tao Liu
  • Tim J. Yen
Chapter

Introduction

Due to diverse and complex genetic abnormalities in different cancers, there are no silver bullets in cancer treatment. According to the NCI (www.cancer.gov/), chemotherapy, together with radiotherapy and surgery, are the three major modalities of cancer treatment.

As uncontrolled proliferation is the most distinctive characteristic of cancer cells, many anticancer drugs directly inhibit growth. These include drugs that target DNA or nucleotide metabolism and cell division. In a cell division cycle, mitosis is the phase during which duplicated sister chromatids physically separate from each other to produce two genetically identical daughter cells. Chemical compounds that interfere with this process should in principle be efficient inhibitors of cell proliferation. However, currently available anticancer drugs of this class are limited to two types of plant alkaloids: taxanes (docetaxel, paclitaxel) and vinca alkaloids (vinblastine, vincristine, vindesine, vinorelbine)....

Keywords

Aurora Kinase Mitotic Arrest Kinetochore Protein Spindle Checkpoint Mitotic Checkpoint 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Fox Chase Cancer CenterPhiladelphiaU.S.A

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