Roles of Centromeres and Kinetochores in Meiosis
Meiosis is the cell division process by which haploid gametes are produced from a diploid progenitor cell. Reduction of the genome by half requires that DNA replication is followed not by one nuclear division, as in mitosis, but by two consecutive divisions. The sorting and segregation of chromosomes during these two nuclear divisions is tightly controlled, thereby ensuring that each of the gametes inherits a complete haploid set of chromosomes. Errors in chromosome segregation during meiosis generate gametes with too few or too many chromosomes, a condition known as aneuploidy, which is associated with birth defects and infertility (Hassold and Hunt, 2001). This chapter reviews our current understanding of the role the centromere and kinetochore play in bringing about the specialized segregation of chromosomes during meiosis.
Overview of Meiosis and the Role of the Kinetochore
Centromere is the name given to the chromosomal DNA onto which the large macromolecular complex, known as the...
KeywordsSister Chromatid Fission Yeast Spindle Assembly Checkpoint Cohesin Complex Sister Kinetochore
I am grateful to Angelika Amon, Kevin Hardwick, Hiro Ohkura and Alison Pidoux for helpful comments on the manuscript and to the Wellcome Trust for funding. I apologise to those colleagues whose work I was unable to cite directly due to space restrictions.
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