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Post-Translational Modifications that Regulate Kinetochore Activity

  • Chitra V. Kotwaliwale
  • Sue Biggins
Chapter

Introduction

To ensure accurate chromosome segregation, the interactions between kinetochores and microtubules must be precisely regulated throughout every mitotic and meiotic cell cycle. Following genome replication, the kinetochores of duplicated chromosomes (sister chromatids) must make bioriented attachments to microtubules arising from opposite spindle poles to ensure that chromosomes are properly segregated at anaphase (see Chapters 2 and 10 for details). At metaphase, sister kinetochores come under tension due to the pulling forces of microtubules on linked sister chromatids. When the cell does not make proper kinetochore–microtubule attachments, a signal transduction system called the spindle checkpoint delays the metaphase to anaphase transition to give the cell time to correct the defects (for review, see Musacchio and Salmon 2007). Elucidating the mechanisms that control kinetochore function is daunting given the extensive number of kinetochore proteins that have recently...

Keywords

Chromosome Segregation Aurora Kinase Kinetochore Protein Spindle Checkpoint Kinetochore Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank all past and present members of the Biggins lab for thoughtful discussions regarding the regulation of kinetochore activity by post-translational modifications. We also thank Bungo Akiyoshi, Suzanne Furuyama and Leigh Ann Higa for critical comments on the manuscript. We apologize to our colleagues whose work we omitted due to space considerations. C. V. K. was supported by a DOD Breast Cancer predoctoral fellowship. Work in the Biggins' laboratory is funded by NIH grants R01 GM078069 and R01 GM064386. S. B. is a Scholar of the Leukemia and Lymphoma Society.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Division of Basic Sciences, Fred Hutchinson Cancer Research CenterSeattle

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