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Centromeres and Kinetochores: An Historical Perspective

  • Kerry S. Bloom
Chapter

Identification of Yeast Centromere DNA

As a preface of tribute to Centromere and Kinetochore function, it is interesting to reflect upon the discovery of chromosomes in the late 1880s when chromosomes were named (HWG von Waldeyer, 1888) and their function in heredity proposed by Boveri and Sutton’s “Chromosome Theory of Inheritance” to almost 100 years later when the elements of chromosome propagation, namely centromere, telomere, and origins of replication were clearly identified. One can only imagine that the excitement in the field in the early 1880s was matched by the bold proposal that chromosomes were the unit of inheritance by Thomas Hunt Morgan in 1915 and contained the hereditary material. The DNA was discovered by Freidrich Meischer in 1869. It is noteworthy that it took almost 30 years after the determination of the double helical DNA structure, in 1953, to identify the sequence elements of chromosome structure. Identifying genes was child’s play in comparison. The...

Keywords

Spindle Pole Postdoctoral Fellow Kinetochore Protein Human Artificial Chromosome Sister Centromere 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of BiologyUniversity of North Carolina at Chapel HillChapel Hill

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