Molecular Targeted Therapies in T-Cell Acute Lymphoblastic Leukemia

  • Alejandro Gutierrez
  • A. Thomas Look


T cell precursors arise from hematopoietic progenitors in the bone marrow and migrate to the thymus, where they undergo a series of proliferation and differentiation steps that include the somatic recombination of T cell receptor (TCR) gene loci (Market and Papavasiliou 2003). TCR gene rearrangements are followed by positive and negative selection steps that allow the survival of T cells only if their TCR functions appropriately within the context of an individual’s immune microenvironment. This highly regulated developmental process results in the generation of a population of T cells with a wide range of somatically acquired T cell receptor variation, which forms the foundation of a fully competent adaptive immune system that can respond to a countless variety of foreign antigens. Genetic alterations involving oncogenes or tumor suppressors can result in the aberrant proliferation, differentiation arrest, and clonal expansion of T cell precursors that is characteristic of T cell acute lymphoblastic leukemia (T-ALL)


NOTCH1 Signaling Oncogenic Transcription Factor Cell Lymphoblastic Lymphoma Activate NOTCH1 Mutation Negative Selection Step 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of Pediatric OncologyDana-Farber Cancer Institute and Children’s Hospital BostonBostonUSA
  2. 2.Harvard Medical SchoolBostonUSA

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