New Therapeutic Frontiers for Childhood Non-Hodgkin Lymphoma



Childhood non-Hodgkin lymphoma (NHL) accounts for approximately 6 to 7% of all childhood cancers diagnosed below the age of 15 in the United States and consists of four major histological subtypes of both intermediate and high-grade NHL including Burkitt lymphoma (BL), lymphoblastic lymphoma (LL), diffuse large B-cell lymphoma (DLBCL), and anaplastic large cell lymphoma (ALCL) (Cairo et al. 2005). While there are a large number of other histological subtypes of NHL that may occur in children, they only account for <5% of all cases of NHL diagnosed in the United States and Western Europe. Posttransplant lymphoproliferative disease (PTLD) may also occur in children following either solid organ transplantation or mismatched or T-cell depleted allogeneic stem cell transplantation and will be the subject of a separate chapter in this monograph. We will focus our discussion on the four major histological subtypes that account for >95% of all NHL in children (Cairo et al. 2005; Pinkerton 2005).


Anaplastic Lymphoma Kinase Burkitt Lymphoma Anaplastic Large Cell Lymphoma Lymphoblastic Lymphoma Denileukin Diftitox 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to thank Erin Morris for her assistance in the development of this manuscript and Sean Park for his preparation of the ALCL figures. Supported in part by grants from the Pediatric Cancer Research Foundation, Andrew Gargiso Foundation, Sonia Scaramella Fund and National Institutes of Health.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Division of Pediatric Blood and Marrow Transplantation, New York-Presbyterian Morgan Stanley Children’s HospitalColumbia UniversityNew YorkUSA

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