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Targeting Degradome Genes via Engineered Viral Vectors

  • Risto Ala-aho
  • Andrew H. Baker
  • Veli-Matti Kähäri

Abstract

Members of the degradome play an important role at different levels in carcinogenesis, tumor progression, invasion, and metastasis. Therefore, they are attractive targets for therapeutic intervention in cancer. Accordingly, wild-type or modified genes coding for different inhibitory molecules targeted at different levels of protease expression and activity have been extensively studied in experimental models of cancer using engineered viral vectors for gene delivery. These preclinical studies have served as an important and efficient way of target validation and proved the feasibility of the concept of protease targeting in cancer therapy. In this chapter, we discuss the application of different viral gene delivery vectors for targeting expression and function of the extracellular matrix degrading proteases.

Keywords

Gene Delivery Helper Virus Oncolytic Adenovirus Herpes Simplex Virus Gene Delivery Vector 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Risto Ala-aho
    • 1
  • Andrew H. Baker
    • 2
  • Veli-Matti Kähäri
    • 1
  1. 1.Department of Dermatology and MediCity Research LaboratoryUniversity of TurkuTurkuFinland
  2. 2.British Heart Foundation Glasgow, Cardiovascular Resarch CentreUniversity of GlasgowGlasgowUK

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