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TIMP-1 as a Prognostic Marker in Colorectal Cancer

  • Camilla Frederiksen
  • Anne Fog Lomholt
  • Hans Jørgen Nielsen
  • Nils Brünner

Abstract

Colorectal cancer (CRC) accounts for about 1 million new cases per year worldwide and is the third most prevalent cancer in Europe, and the second most important in relation to cancer-specific death. Outcome in patients with CRC relates to the stage of disease at diagnosis. The staging is based on histopathological characteristics and has limitations especially concerning the prediction of prognosis for patients presenting with the intermediate tumour stages (II and III). A number of publications have suggested tissue inhibitor of metalloproteinases 1 (TIMP-1) as a new and valid prognostic marker in CRC. This chapter reviews the literature on TIMP-1 as a prognostic marker in CRC.

Keywords

Colorectal Cancer Prognostic Marker Tissue Inhibitor Human Breast Epithelial Cell Vascular Epidermal Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Camilla Frederiksen
    • 1
  • Anne Fog Lomholt
    • 1
  • Hans Jørgen Nielsen
    • 1
  • Nils Brünner
    • 2
  1. 1.Department of Surgical Gastroenterology 435Copenhagen University Hospital HvidovreHvidovreDenmark
  2. 2.Section of Biomedicine, Department of Veterinary Pathobiology, Faculty of Life SciencesUniversity of CopenhagenFrederiksberg CDenmark

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