TIMP-1 as a Prognostic Marker in Colorectal Cancer
Colorectal cancer (CRC) accounts for about 1 million new cases per year worldwide and is the third most prevalent cancer in Europe, and the second most important in relation to cancer-specific death. Outcome in patients with CRC relates to the stage of disease at diagnosis. The staging is based on histopathological characteristics and has limitations especially concerning the prediction of prognosis for patients presenting with the intermediate tumour stages (II and III). A number of publications have suggested tissue inhibitor of metalloproteinases 1 (TIMP-1) as a new and valid prognostic marker in CRC. This chapter reviews the literature on TIMP-1 as a prognostic marker in CRC.
KeywordsColorectal Cancer Prognostic Marker Tissue Inhibitor Human Breast Epithelial Cell Vascular Epidermal Growth Factor
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