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Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo

  • Jelena Gavrilovic
  • Xanthe Scott

Abstract

Metalloproteinases have been implicated in cell migration in many in vitro model systems which involving tumour cell or leukocyte migration. Here the similarities between the migration mechanisms of amoebae, leukocytes and tumour cells are discussed with a particular focus on recent studies of metalloproteinase dependence in tumour cell migration in three dimensional matrices. Some novel in vivo model systems where metalloproteinases or serine proteinases have been explored are discussed. Finally certain matricryptic sites exposed following metalloproteinase remodelling of the extracellular matrix are also considered.

Keywords

Cell Migration Transendothelial Migration Cryptic Site Intact Basement Membrane Tumour Cell Extravasation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Jelena Gavrilovic
    • 1
  • Xanthe Scott
    • 1
  1. 1.Biomedical Research Centre, School of Biological SciencesUniversity of East AngliaNorwichUK

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