Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo
Metalloproteinases have been implicated in cell migration in many in vitro model systems which involving tumour cell or leukocyte migration. Here the similarities between the migration mechanisms of amoebae, leukocytes and tumour cells are discussed with a particular focus on recent studies of metalloproteinase dependence in tumour cell migration in three dimensional matrices. Some novel in vivo model systems where metalloproteinases or serine proteinases have been explored are discussed. Finally certain matricryptic sites exposed following metalloproteinase remodelling of the extracellular matrix are also considered.
KeywordsCell Migration Transendothelial Migration Cryptic Site Intact Basement Membrane Tumour Cell Extravasation
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