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In Vitro and In Vivo Models of Angiogenesis to Dissect MMP Functions

  • Sarah Berndt
  • Françoise Bruyère
  • Maud Jost
  • Agnès Noël

Abstract

Angiogenesis and lymphangiogenesis, the formation of new blood and lymphatic vessels from preexisting ones, are important processes associated with cancer growth and metastatic dissemination. It has become clear that matrix metalloproteinases contribute more to angiogenesis than by just degrading matrix components. They are capable to process a large array of extracellular and cell-surface proteins, and they contribute both in the onset and in the maintenance of angiogenesis. Their implication during lymphangiogenesis is expected, but not yet documented. This chapter describes in vitro and in vivo models which have proven suitability for investigating each step of (lymph)angiogenic processes. Their rationale and limitation is discussed and emerging functions of matrix metalloproteinases are reviewed.

Keywords

Vascular Endothelial Growth Factor Thoracic Duct Lymphatic Endothelial Cell Perivascular Cell Angiogenic Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Sarah Berndt
    • 1
  • Françoise Bruyère
    • 1
  • Maud Jost
    • 2
  • Agnès Noël
    • 1
  1. 1.Laboratory of Tumor and Development BiologyUniversity of LiègeLiège
  2. 2.Laboratory of Tumor and Development Biology, Centre de Recherche en Cancérologie Expérimentale (CRCE), Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-R)University of LiègeLiègeBelgium

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