Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations

  • Karin List
  • Thomas H. Bugge


Recent advances in the mouse and human genome projects have resulted in the identification of a surprisingly large number of genes encoding new proteolytic enzymes which include members of the type II transmembrane serine protease (TTSP) family. In the past few years, the TTSP family has undergone a rapid transformation from a group of largely unexplored proteins into an established family of cell surface-associated proteases playing important roles in development, homeostasis, and pathogenesis. This chapter summarizes current knowledge about the biochemical properties and the biological functions of the TTSP family members in mammalian physiology and disease.


Prostate Cancer Serine Protease Atrial Natriuretic Peptide Biological Chemistry Pathological Function 
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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Karin List
    • 1
  • Thomas H. Bugge
    • 2
  1. 1.Department of Pharmacology and Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroit
  2. 2.Proteases and Tissue Remodeling Unit, Oral and Pharyngeal Cancer BranchNational Institute of Dental and Craniofacial Research, National Institutes of HealthBethesda

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