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Evolutionary Genomics of Hox Gene Clusters

  • Chapter
HOX Gene Expression

Abstract

The evolution of Hox clusters in vertebrates follows different patterns than those of in-vertebrate clusters. More stringent structural constraints in vertebrates are apparent from tighter cluster organization and the systematic expulsion of repetitive material. We speculate that the tendency of vertebrates to maintain Hox clusters after genome duplications might be related to these stricter constraints. Duplications may temporarily lift these constraints, thereby opening a window of adaptive opportunity for functional differentiation of the Hox genes that eventually leads to their fixation.

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Authors and Affiliations

  1. Department of Computer Science and Engineering, Arizona State University, Phoenix, Arizona, USA

    Sonja J. Prohaska

  2. Lehrstuhl für Bioinformatik Institut für Informatik, Universität Leipzig, Leipzig, Germany

    Peter F. Stadler

  3. Barmhertig Brüder-Hospital, A-1020, Wien, Austria

    Günter P. Wagner

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  1. Sonja J. Prohaska
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  2. Peter F. Stadler
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  3. Günter P. Wagner
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Correspondence to Günter P. Wagner .

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Prohaska, S.J., Stadler, P.F., Wagner, G.P. (2007). Evolutionary Genomics of Hox Gene Clusters. In: HOX Gene Expression. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68990-6_5

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