Clinical Applications of Optical Coherence Tomography in Optic Nerve Disease

  • Emely Z. Karam
  • Thomas R. HedgesIII
  • Carlos E. Mendoza

Optical coherence tomography (OCT) is a relatively new technology that provides information about the retina, optic nerve, and nerve fiber layer (NFL) differently from other instruments.1 Newer versions of the OCT allow better resolution, which makes it useful for management of optic nerve disease. For neuro-ophthalmology, OCT methods employed for retinal as well as glaucoma analysis are used, because some optic nerve pathologies have macular complications, but also because many retinal conditions may mimic optic nerve disease.


Optic Nerve Optical Coherence Tomography Optic Disc Retinal Nerve Fiber Layer Optic Nerve Head 


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  1. 1.
    Jaffe GJ, Caprioli J. Optical coherence tomography to detect and manage retinal disease and glaucoma. Am J Ophthalmol 2004;137(1):156–169.PubMedCrossRefGoogle Scholar
  2. 2.
    Krivoy D, Gentile R, Liebmann JM, et al. Imaging congenital optic disc pits and associated maculopathy using optical coherence tomography. Arch Ophthalmol 1996;114(2):165–170; erratum in Arch Ophthalmol 1996;114(7):840.PubMedGoogle Scholar
  3. 3.
    Theodossiadis GP, Theodossiadis PG. Optical coherence tomography in optic disc pit maculopathy treated by the macular buckling procedure. Am J Ophthalmol 2001;132(2):184–190.PubMedCrossRefGoogle Scholar
  4. 4.
    Rutledge BK, Puliafito CA, Duker JS, Hee MR, Cox MS. Optical coherence tomography of macular lesions associated with optic nerve head pits. Ophthalmology 1996;103(7):1047–1053.PubMedGoogle Scholar
  5. 5.
    Konno S, Akiba J, Sato E, Kuriyama S, Yoshida A. OCT in successful surgery of retinal detachment associated with optic nerve head pit. Ophthalmic Surg Lasers 2000;31(3):236–239.PubMedGoogle Scholar
  6. 6.
    Landau K, Djahanshahi-Bajka J, Kirchschläger BM. Topless optic discs in children of mothers with type I diabetes mellitus. Am J Ophthalmol 1998;125(5):605–611.PubMedCrossRefGoogle Scholar
  7. 7.
    Unoki K, Ohba N, Hoyt WF. Optical coherence tomography of superior segmental optic hypoplasia. Br J Ophthalmol 2002;86: 910–914.PubMedCrossRefGoogle Scholar
  8. 8.
    Becquet F, Ducournau D, Ducournau Y, Goffart Y, Spencer WH. Juxtapapillary subretinal pigment epithelial polypoid pseudocysts associated with unilateral tilted optic disc. Ophthalmology 2001;108:1657–1662.PubMedCrossRefGoogle Scholar
  9. 9.
    Fournier AV, Damji KF, Epstein DL, Pollock SC. Disc excavation in dominant optic atrophy. Differentiation from normal tension glaucoma. Ophthalmology 2001;108:1595–1602.PubMedCrossRefGoogle Scholar
  10. 10.
    Roh S, Noecker RJ, Schumman J, Hedges TR III, Weiter JJ, Mattox C. Effect of optic nerve head drusen on nerve fiber layer thickness. Ophthalmology 1998;105(5):878–885.PubMedCrossRefGoogle Scholar
  11. 11.
    Roh S, Noecker RJ, Schumman J. Evaluation of coexisting optic nerve head drusen and glaucoma with optical coherence tomography. Ophthalmology 1997;104(7):1138–1144.PubMedGoogle Scholar
  12. 12.
    Ocakoglu O, Ustundag C, Koyluoglu N, Oguz V, Kendiroglu G, Ozkan S. Long term follow-up of retinal nerve fiber layer thickness in eyes with optic nerve head drusen. Curr Eye Res 2003;26(5):277–280.PubMedCrossRefGoogle Scholar
  13. 13.
    Karam EZ, Hedges TR, Szwarts. Optical coherence tomography shows increased nerve fiber layer thickness in pseudo- and mild papilledema. Association for Research in Vision and Opthalmology (ARVO) Meeting Abstracts 1998;704(B627):S150.Google Scholar
  14. 14.
    Hoye VJ, Berroca AM, Hedges TR III, Amaro ML. Optical coherence tomography demonstrates subretinal macular edema from papilledema. Arch Ophthalmol 2001;119:1287–1290.PubMedGoogle Scholar
  15. 15.
    Parisi V. Correlation between morphological and functional retinal impairment in patients affected by ocular hypertension, glaucoma, demyelinating optic neuritis and Alzheimer’s disease. Semin Ophthalmol 2003;18(2):50–57.PubMedGoogle Scholar
  16. 16.
    Parisi V, Manni G, Spadaro M, et al. Correlation between morphological and functional retinal impairment in multiple sclerosis patients. Invest Ophthalmol Vis Sci 1999;40(11):2520–2527.PubMedGoogle Scholar
  17. 17.
    Gray RH. Unilateral enlargement of the blind spot: a diagnostic dilemma. Br J Ophthalmol 2002;86(8):936–938.PubMedCrossRefGoogle Scholar
  18. 18.
    Karam EZ, Morales SJ, Belloso M, Perret K. Optical coherence tomography: a new tool in the diagnosis of big blind syndrome. Poster presented at North American Neuro-ophthalmology Society Meeting, March 27 to April 1, 2004, Orlando, FL.Google Scholar
  19. 19.
    Apple DJ, Craythorn JM, Reidy JJ, Steinmetz RL, Brady SE, Bohart WA. Malignant transformation of an optic nerve melanocytoma. Can J Ophthalmol 1984;19(7):320–325.PubMedGoogle Scholar
  20. 20.
    Shields JA, Shields CL, Eagle RC Jr, Lieb WE, Stern S. Malignant melanoma associated with melanocytoma of the optic disc. Ophthalmology 1990;97(2):225–230.PubMedGoogle Scholar
  21. 21.
    Meyer D, Ge J, Blinder KJ, Sinard J, Xu S. Malignant transformation of an optic disc melanocytoma. Am J Ophthalmol 1999;127(6):710–714.PubMedCrossRefGoogle Scholar
  22. 22.
    Shields JA, Shields CL, Eagle RC Jr, Singh AD, Berrocal MH, Berrocal JA. Central retinal vascular obstruction secondary to melanocytoma of the optic disc. Arch Ophthalmol 2001;119(1):129–133.PubMedGoogle Scholar
  23. 23.
    Antcliff RJ, Ffytche TJ, Shilling JS, Marshall J. Optical coherence tomography of melanocytoma. Am J Ophthalmol 2000;130(6):845–847.PubMedCrossRefGoogle Scholar
  24. 24.
    Medeiros FA, Moura FC, Vessani RM, Susanna R. Axonal loss after traumatic optic neuropathy documented by optical coherence tomography. Am J Ophthalmol 2003;135(3):406–408.PubMedCrossRefGoogle Scholar

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© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Emely Z. Karam
    • 1
  • Thomas R. HedgesIII
    • 2
  • Carlos E. Mendoza
    • 2
  1. 1.Neuro-Ophthalmology Service, Unidad Oftalmologica de CaracasAssociacion Venezolana para el Avance de la OftalmologiaCaracasVenezuela
  2. 2.Neuro-Ophthalmology Service, New England Eye CenterTufts University School of MedicineBoston

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