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Obstetrics

  • Ahmad Wagih Abdel Halim
Chapter

Human Chorionic Gonadotrophin (HCG)

  • Definition: A glycoprotein secreted by syncytiotrophoblast.

  • Production: It starts at implantation (7 days after fertilization) and its levels double every 2 days till it peaks at around 10weeks gestational age (1,000,000 Units). After the peak, level decreases as the pregnancy progresses to full term.

  • Detection: By urine analysis (Standard pregnancy test), or by measuring the beta subunit of HCG in serum (More sensitive and specific).

  • Uses of HCG:
    1. 1.

      Diagnosis of pregnancy: Appears in the urine 8 days after fertilization.

       
    2. 2.

      Diagnosis and follow up of some ovarian and trophoblastic tumors.

       
    3. 3.

      Evaluation of threatened abortion: If levels are doubling every 2 days, pregnancy is still intact. If no doubling, suspect missed abortion. Explained in detail later.

       
  • Functions of HCG:
    1. 1.

      Maintains corpus luteum until placental function is well established. (10weeks).

       
    2. 2.

      Stimulates fetal testicular function in utero if the fetus is male.

       
  • Note:...

Keywords

Amniotic Fluid Corpus Luteum Human Chorionic Gonadotrophin Fetal Heart Rate Uterine Contraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.McLaren Regional Medical CenterFlintUSA

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