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Epigenetic Markers of Ovarian Cancer

  • Caroline A. Barton
  • Susan J. Clark
  • Neville F. Hacker
  • Philippa M. O’Brien
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 622)

Ovarian cancer is the fourth leading cause of cancer death in women, and has the highest mortality rate of the reproductive cancers (1). Ovarian cancer is often asymptomatic in its early stages and because of lack of early detection strategies, most patients are diagnosed with disseminated disease, for whom the 5-year overall survival rate is only 20% (2). In the absence of an early detection test, improved therapies for advanced disease are critical to improving the survival for women with ovarian cancer. Most patients receive cytotoxic chemotherapy following surgical resection of their tumor; however, although the majority of patients are initially responsive to chemotherapy, most of them eventually develop drug-resistant disease, that is essentially incurable. A better understanding of the molecular pathogenesis underlying ovarian cancer is the key to identifying markers for early detection and novel therapeutics.

Keywords

Ovarian Cancer Ovarian Carcinoma Epithelial Ovarian Cancer Promoter Methylation Ovarian Cancer Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Caroline A. Barton
    • 1
  • Susan J. Clark
  • Neville F. Hacker
  • Philippa M. O’Brien
  1. 1.Ovarian Cancer CenterGarvan InstituteSydneyAustrailia

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