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Ovarian Cancer pp 273-280 | Cite as

Role of Vascular Leukocytes in Ovarian Cancer Neovascularization

  • Klara Balint
  • Jose R. Conejo-Garcia
  • Ron Buckanovich
  • George Coukos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 622)

Tumor angiogenesis is a process that allows primary tumors to grow beyond the approximate size of 1–2mm3. It has been shown that if cancer cells are placed in an avascular site like rabbit cornea, and the capillaries are physically prevented from reaching the implant or were inhibited from undergoing angiogenesis, tumor growth is dramatically impaired, restricting the tumor size to 0.4mm (15). In the absence of adequate vasculature, tumor cells become apoptotic or necrotic (4). It is now wellaccepted that antiangiogenic therapy, originally proposed by Judah Folkman (14), is a promising strategy against cancer. Recent trials with bevacizumab, an antibody against vascular endothelial growth factor (VEGF) used alone or in combination with chemotherapy, showed that systemic antiangiogenic therapy may indeed have a measurable impact on cancer progression and patient survival (31).

During embryogenesis, the formation and remodeling of new blood vessels occurs in two different ways: (1) angiogenesis-new vessels sprout and mature from preexisting vasculature, and (2) vasculogenesis-the new vessels are born from progenitor cells. In adults, new vessels are produced physiologically only via angiogenesis. For example in females, reproductive organs are formed during the follicular and menstrual cycles. Adult neovascularization occurs largely under pathologic situations, such as wound healing and tumor growth. The vascularization in malignant tumors happens through several different mechanisms, which are not mutually exclusive and very often occur concurrently (10, 17).

Keywords

Vascular Endothelial Growth Factor Ovarian Cancer Dendritic Cell Hematopoietic Stem Cell Endothelial Progenitor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Klara Balint
  • Jose R. Conejo-Garcia
  • Ron Buckanovich
  • George Coukos
    • 1
  1. 1.Center for Research on the Early Detection and Cure of Ovarian CancerUniversity of PennsylvaniaPhiladelphia

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