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Ovarian Cancer pp 169-181 | Cite as

Syngeneic Mouse Model of Epithelial Ovarian Cancer: Effects of Nanoparticulate Paclitaxel, Nanotax®

  • Katherine F. Roby
  • Fenghui Niu
  • Roger A. Rajewski
  • Charles Decedue
  • Bala Subramaniam
  • Paul F. Terranova
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 622)

In 2006, it has been estimated that 20,180 women in the United States will be diagnosed with ovarian cancer, and 15,310 women will die from the disease (1). Although advances have occurred in treatment strategies, success remains limited (1). The median overall survival for patients with advanced ovarian cancer and receiving the current standards of treatment (surgery and paclitaxel/platinum chemotherapy) is 36–39 months (2). The realities of the overall statistics are sobering. Future success in the treatment of women with ovarian cancer, including those diagnosed with late stage disease, will be dependent on the development of novel approaches to treatment. Until recently, limited progress has been made in the development of new treatments largely because of a lack of laboratory animal model systems of ovarian cancer.

Keywords

Ovarian Cancer Epithelial Ovarian Cancer Ascites Fluid Supercritical Carbon Dioxide Intraperitoneal Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • Katherine F. Roby
    • 1
  • Fenghui Niu
    • 2
  • Roger A. Rajewski
    • 2
  • Charles Decedue
    • 2
  • Bala Subramaniam
    • 3
  • Paul F. Terranova
    • 4
  1. 1.Department of Anatomy & Cell BiologyUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.Higuchi Biosciences CenterUniversity of KansasLawrenceUSA
  3. 3.Department of Chemical and Petroleum EngineeringUniversity of KansasLawrenceUSA
  4. 4.Department of Molecular & Integrative PhysiologyUniversity of Kansas Medical CenterKansas CityUSA

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