Solid-Pseudopapillary Neoplasm

  • David C. Chhieng
  • Edward B. Stelow
Part of the Essentials in Cytopathology book series (EICP, volume 3)


Also known as solid-cystic tumor, papillary-cystic tumor, and solid and papillary tumor of the pancreas, this low-grade primary pancreatic epithelial neoplasm accounts for 1% of all exocrine pancreatic neoplasms. It occurs predominantly in adolescent girls and young women and is rare in men and children. Patients often present with vague abdominal discomfort/pain and an enlarging abdominal mass. Not infrequently, patients are asymptomatic and the tumors are found incidentally on physical examination or by imaging for the workup for unrelated conditions. Jaundice and hormonal disturbances are rare. Ultrasound and computed tomography (CT) usually reveal a well-demarcated and variably cystic mass, averaging 10cm and usually located in the body or tail of the pancreas. Tumor calcification may be present. As smaller tumors are identified with the increased use of more sensitive imaging techniques, cystic degeneration and calcification are often not seen.


Intraductal Papillary Mucinous Neoplasm Acinar Cell Carcinoma Pancreatic Endocrine Tumor Cystic Degeneration Necrotic Debris 
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Suggested Reading

  1. Bardales RH, Centeno B, Mallery JS, et al. Endoscopic ultrasoundguided fine needle aspiration cytology diagnosis of solid-pseudopapillary tumor of the pancreas. Am J clin Pathol 2004;121:654–662.PubMedCrossRefGoogle Scholar
  2. Klimstra DS, Wenig BM, Heffess CS. Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential. Semin Diagn Pathol 2000;17:66–80.PubMedGoogle Scholar
  3. Notohara KMD, Hamazaki SMD, Tsukayama CMD, et al. Solid-pseudopapillary tumor of the pancreas: immunohistochemical localization of neuroendocrine markers and Cd10. Am J Surg Pathol 2000;24:1361–1371.PubMedCrossRefGoogle Scholar
  4. Pettinato G, Di Vizia D, Maninvel JC, Pambuccian SE, Somma P, Insabato L. Solid-pseudopapillary tumor of the páncreas—a neoplasm with distinct and highly characteristic nuclear features. Diagn Cytopathol 2002;27:325–334.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • David C. Chhieng
    • 1
  • Edward B. Stelow
    • 2
  1. 1.Department of PathologyUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Department of PathologyUniversity of VirginiaCharlottesvilleUSA

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