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Acinar Cell Carcinoma

  • David C. Chhieng
  • Edward B. Stelow
Part of the Essentials in Cytopathology book series (EICP, volume 3)

Abstract

Acinar cell carcinoma (ACC) is a rare malignant epithelial neoplasm of the exocrine pancreas. It mostly affects older individuals; however, it can occur in individuals of any age, from 3 to 90 years. It is slightly more common in men. The neoplasms most often arise in the head of the pancreas and may have developed both lymph node and liver metastases at time of diagnosis. Most patients present with nonspecific abdominal complaints, and biliary obstruction is uncommon. Rarely, patients may display symptoms associated with increased serum levels of pancreatic enzymes, such as distal fat necrosis or arthralgias.

Keywords

Cytologic Feature Islet Cell Tumor Acinar Cell Carcinoma Pancreatic Endocrine Tumor Loose Cluster 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Suggested Reading

  1. Klimstra DS, Heffess CS, Oertel JE, Rosai J. Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. Am J Surg Pathol 1992;16:815–837.PubMedCrossRefGoogle Scholar
  2. Klimstra DS, Longnecker D. Acinar cell carcinoma. In: Hamilton SR, Aaltonen LA, eds. Pathology and genetics of tumours of the digestive system. France, Lyon: IARC Press; 2000:241–243.Google Scholar
  3. Labate AM, Klimstra DL, Zakowski MF. Comparative cytologic features of pancreatic acinar cell carcinoma and islet cell tumor. Diagn Cytopathol 1997;16:112–116.PubMedCrossRefGoogle Scholar
  4. Stelow EB, Bardales RH, Shami VM, et al. Cytology of pancreatic acinar cell carcinoma. Diagn Cytopathol 2006;34:367–372.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • David C. Chhieng
    • 1
  • Edward B. Stelow
    • 2
  1. 1.Department of PathologyUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Department of PathologyUniversity of VirginiaCharlottesvilleUSA

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