Epidemiology of EBV Infection

  • Rosemary Rochford


Following the discovery of EBV, studies by Gertrude and Werner Henle and others were done to determine the distribution of EBV in the general population. Because EBV was initially isolated from a Burkitt’s lymphoma cell line, there was some thought that the virus would not be very prevalent and would be geographically restricted like the tumor from which it was derived. As it turned out, EBV is ubiquitous in the world’s population with an estimated greater than 90% of adults worldwide infected. Even remote populations such as those living in the Melansian islands or the jungles of the Amazon are infected with EBV (Black et al. 1970; Lang et al. 1977). For most, primary infection is asymptomatic and the virus remains as a benign latent infection for the lifetime of the host. But primary infection in young adulthood can cause infectious mononucleosis, a benign self-limiting disease. In addition, EBV has been associated with a number of different malignancies in both...


Burkitt Lymphoma Infectious Mononucleosis Maternal Antibody Cervical Secretion Heteroduplex Tracking Assay 
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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologySUNY Upstate Medical UniversitySyracuseUSA

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