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Primate Models for Gammaherpesvirus-Associated Malignancies

  • Ilhem Messaoudi
  • Blossom Damania
  • Scott W. Wong
Chapter

Introduction

Non-human primates (NHP) represent an invaluable resource for elucidating and understanding disease processes in humans, as humans and NHP share close developmental, physiological and evolutionary relationships (Hendrickx and Binkerd 1990). For infectious disease research, NHP have historically played an important role as they are either susceptible to infectious agents that cause disease in humans (Kirschstein et al. 1960) or harbor infectious agents that are closely related to those that infect and cause disease in humans (Wenner et al. 1975). For example, NHP harbor herpesviruses that have co-evolved with their hosts and are genetically more closely related to human herpesviruses than other mammalian herpesviruses. More importantly, these simian herpesvirus homologues, which include alpha (α), beta (β) and gamma(γ)herpesviruses, are capable of causing similar, if not identical, disease manifestations in their natural host, which makes them excellent models to dissect...

Keywords

Rhesus Macaque Simian Immunodeficiency Virus Squirrel Monkey World Monkey World Primate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Ilhem Messaoudi
  • Blossom Damania
  • Scott W. Wong
    • 1
  1. 1.Vaccine and Gene Therapy Institute, Oregon Health & Science UniversityOregon 97006USA

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