HHV-8/KSHV Proteins Involved in Signaling and Transformation

  • Silke Hartmann
  • Thomas F. Schulz
  • John Nicholas


When the first partial and complete sequences of Kaposi’s sarcoma herpesvirus were obtained (Neipel et al. 1997; Nicholas et al. 1997; Russo et al. 1996), it became apparent that the presence of multiple viral genes with low but significant homologies to mammalian proteins involved in signal transduction is one of the key features of this virus. While equivalents of some of these homologues had been found in other herpesviruses or other large DNA viruses, for example chemokines and chemokine receptors, others such as interleukin-6 had not previously been identified in a virus. Given the low sequence homology to their cellular counterparts and the fact that some of the cellular gene homologues occur in different large DNA viruses, it seems that such homologues have entered their respective viral genomes a long time ago in the early phases of DNA virus evolution. Their continued presence, however, points to a selective advantage during virus evolution, probably by...


Vascular Endothelial Growth Factor Angiogenic Cytokine Lytic Replication KSHV Infection Viral Oncogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



JN is funded by grants CA76445, CA136356, CA119887 and CA113239 from the National Institutes of Health, U.S.A, and is grateful for the general support of his colleagues in the Viral Oncology Program of the Department of Oncology, Johns Hopkins School of Medicine.

SH is funded by grants Graduate School 745, and SFB 566 from the Deutsche Forschungsgemeinschaft (DFG), Germany, and by the European Union Integrated Project INCA LSHC-CT-2005-018704. She s grateful for the general support and helpful discussions at the Institute of Virology, Hanover Medical School.


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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Silke Hartmann
  • Thomas F. Schulz
    • 1
  • John Nicholas
    • 2
  1. 1.Institute of VirologyHannover Medical SchoolHannoverGermany
  2. 2.Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins UniversityBaltimoreUSA

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