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KSHV Latent Genes and Their Regulation

  • Dirk P. Dittmer
Chapter
Herpesviridae are divided into three groups: alpha herpesviruses, beta herpesviruses and gamma herpesviruses. Only the two gamma herpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8) and Epstein–Barr virus (EBV, or human herpesvirus 4) are associated with human cancer. Herpesvirus lytic replication is also customarily divided into three phases: alpha or immediate early (IE), beta or early (E) and gamma or late (L). We base this classification on the temporal order of viral gene expression. Here, I propose that KSHV latent genes likewise may be divided into three categories based upon their pattern of transcription in KSHV-associated diseases (Table 20.1).
Table 20.1

The three categories of KSHV latency

 

KS

(in situ)

PEL, MCD

(in situ)

TPA inducible

Genes

Type I

100%

100%

Minimal

LANA*, vFLIP*, vCYC*

Type II

0%

100%

Not inducible

LANA-2/vIRF-3

Type III

100%

100%

Maximal

Kaposin*, K9/vIRF-1*

*A second, proximal promoter drives transcription in response to...

Keywords

Core Promoter Primary Effusion Lymphoma Immediate Early Lytic Reactivation Multicentric Castleman Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

Work in the authors group is supported by funding from the Leukemia and Lymphoma Society and NIH (CA109232). Thanks to Drs. Blossom A. Damania and Michelle R. Staudt for illuminating discussions.

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© Springer Science + Business Media, LLC 2009

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  • Dirk P. Dittmer

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