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DNA Tumor Viruses pp 25–52Cite as

Transformation by Polyomaviruses

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Abstract

Polyomaviruses are small DNA tumor viruses that encode tumor antigens which interfere with the two major tumor suppressor pathways, pRB and p53. The viral early proteins have been utilized by researchers as model systems to decipher mechanisms relating to oncogenesis and tumorigenesis. Investigation of molecular mechanisms of these early proteins has contributed significantly to our understanding of cell cycle regulation, cell proliferation and growth, and signal transduction pathways. This chapter discusses the oncoproteins of polyomaviruses and how they induce cellular transformation.

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Acknowledgments

We thank the members of our laboratory for valuable suggestions and helpful comments. This work was supported by NIH grant CA118970.

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Authors and Affiliations

  1. Department of Microbiology and Immunology and Comprehensive Cancer Center, University of Michigan Medical School, 1500 E. Medical Center Dr., 6304 Cancer Center, Ann Arbor, MI 48109-0942, USA

    Michael J. Imperiale

Authors
  1. Dweepanita Das
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  2. Michael J. Imperiale
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Correspondence to Michael J. Imperiale .

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Editors and Affiliations

  1. University of North Carolina Chapel Hill, NC, USA

    Blossom Damania

  2. University of Pittsburgh Pittsburgh, PA, USA

    James M. Pipas

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© 2009 Springer Science + Business Media, LLC

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Das, D., Imperiale, M.J. (2009). Transformation by Polyomaviruses. In: Damania, B., Pipas, J.M. (eds) DNA Tumor Viruses. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68945-6_2

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