Introduction to Diseases Associated with Kaposi’s Sarcoma-Associated Herpesvirus

  • Patrick S. Moore
  • Yuan Chang

Investigation of Kaposi’s sarcoma-associated herpesvirus (KSHV or HHV8) has opened new areas of research in basic cell biology, tumor virology and clinical medicine. KSHV is the cause of Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL) and some forms of multicentric Castleman’s disease (MCD), as well as some nonmalignant syndromes such as acute bone marrow failure. Studies characterizing this virus stand as a model for investigating the role of a newly discovered virus in human disease. The initial description of KSHV in 1994 was based on fundamental observations extending back over a century.

Kaposi’s Sarcoma

Kaposi’s sarcoma (KS) was first described by the Austro-Hungarian dermatologist Moriz Kaposi (Fig. 18.1) in 1872 as an “idiopathic multiple pigmented sarcoma of the skin” (Kaposi 1872). Kaposi was born Moriz Kohn in 1837 to a poor family in the Kaposvár region of Austro-Hungary and changed his name to Kaposi in 1871. With the support of his family, he completed university...


Primary Effusion Lymphoma Representational Difference Analysis KSHV Infection Primary Effusion Lymphoma Cell KSHV Genome 
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© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  1. 1.Molecular Virology ProgramUniversity of Pittsburgh Cancer InstitutePittsburghUSA
  2. 2.Molecular Virology ProgramUniversity of Pittsburgh Cancer InstitutePittsburghUSA

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