The Epstein–Barr Virus Lytic Life Cycle

  • Sankar Swaminathan
  • Shannon Kenney


The lytic phase of Epstein–Barr virus (EBV; Zalani et al. 1996) infection is an essential part of the virus life cycle, since only this form of viral replication results in the production of infectious viral particles, and allows the virus to be transmitted from cell to cell and host to host. Although development of EBV-associated malignancy is primarily associated with growth of latently EBV-infected cells, immunosuppressed patients often have abnormally high levels of infectious viral particles in their plasma, and enhanced intercellular transmission of virus may play a role in increasing the likelihood that immunosuppressed patients eventually develop EBV-induced lymphoproliferative disease (LPD) (Cohen 2000; Feng et al. 2004a) Anti-viral drugs (acyclovir and ganciclovir) which inhibit the lytic form of EBV replication decrease the risk of post-transplant lymphoproliferative disease in renal transplant recipients (Funch et al. 2005). In addition, early-passage B cells...


Tegument Protein Lytic Replication Lytic Form Oral Hairy Leukoplakia Bart miRNAs 
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© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of MedicineUniversity of FloridaGainesvilleUSA
  2. 2.Departments of Medicine & Medical Microbiology and Immunology, McArdleLaboratory for Cancer Research University of WisconsinMadisonUSA

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