Epstein–Barr Virus Transforming Proteins: Biologic Properties and Contribution to Oncogenesis

  • Nancy Raab-Traub


The Epstein–Barr virus (EBV) is perhaps the most successful human herpesvirus in that greater than 95% of the world’s population are infected (Kieff and Rickinson 2001). The virus establishes a persistent usually benign infection that is marked by the presence of EBV-infected B-lymphocytes in the peripheral blood and continued secretion of low levels of virus in saliva (Miller et al. 1973). EBV is the prototype of the gamma herpesviruses. The gamma herpesviruses are distinguished by their ability to remain dormant in lymphoid cells and the ability to expand the infected cell population to induce cell growth. Pathogenesis induced by these viruses usually results from uncontrolled cellular replication rather than cell death caused by viral replication. EBV is linked to the development of several malignancies, primarily of lymphoid and epithelial cell origin (Raab-Traub 1996). These cancers include African Burkitt's lymphoma, post-transplant lymphoma (PTL), AIDS-associated...


Epidermal Growth Factor Receptor Ubiquitin Ligase Latent Membrane Protein Growth Transformation LMP2 Expression 
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© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  1. 1.Professor, Department of Microbiology & Immunology, Lineberger Comprehensive Cancer CenterUniversity of North CarolinaChapel HillNorth Carolina

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