Paget’s Disease


Mammary and extramammary Paget’s disease represent two clinical conditions with potentially serious consequences for the patient. Mammary Paget’s disease is associated with underlying carcinoma of the breast in virtually all cases. Exact incidence numbers vary, but with meticulous serial sections of major ducts entering into the nipple, foci of ductular carcinoma are identified in most cases (1). The disease has the same epidemiologic characteristics as breast carcinoma, independent of the presence of Paget’s disease. It is most frequently encountered in middle-aged to elderly women and it may be unilateral or bilateral. Mammary Paget’s disease presents as an erythematous, scaling patch on the nipple (Figure 9.1).


Underlying Tumor Anogenital Region Upward Extension Major Duct Underlying Carcinoma 
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© Springer Science+Business Media, LLC 2007

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