Mast Cell Disease (Urticaria Pigmentosa)


Cutaneous mast cell disease has several different manifestations. It can present during the neonatal period or throughout life. Different age populations generally develop different clinical manifestations and different associated conditions. It is the systemic form of mastocytosis in adults that has the most potentially severe complications. It has been estimated that from 15% to 50% of patients with adult-onset mast cell disease will have systemic involvement (1,2). However, for the sake of completeness, the other variants of this disease spectrum will also be considered. Urticaria pigmentosa is the global term for all conditions that are characterized by increased numbers of mast cells within the dermis. There is no gender predilection.


Mast Cell Systemic Mastocytosis Urticaria Pigmentosa Mast Cell Leukemia Mast Cell Disease 
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