Leukemia cutis is an uncommon cutaneous eruption that may be difficult to diagnose. In the vast majority of patients, there is a known history of leukemia at the time of the skin manifestations. However, leukemia may have its initial manifestation in the skin, in some cases with simultaneous bone marrow involvement, or less commonly, in the absence of simultaneous marrow involvement. (In these cases, the cutaneous eruptions have been called extramedullary myeloid tumors (1)). In one series, approximately 38% of patients had cutaneous findings at the time of bone marrow diagnosis (2). In other series, anywhere from 3% to 7% of patients had cutaneous lesions prior to detection of marrow involvement (3). Patients with all types of leukemia may demonstrate cutaneous lesions. It has been reported in 2% to 3% of patients with acute myelogenous leukemia (4). Cutaneous involvement is less common in patients with acute lymphoblastic leukemia (5). Chronic myelogenous leukemia patients have skin manifestations in 6% to 20% of cases (6). The incidence ranges from 4% to 20% in patients with chronic lymphocytic leukemia (7).


Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia Herpes Zoster 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Traweek ST, Arber DA, Rappaport H, Brynes RK. Extramedullary myeloid cell tumors: An immunohistochemical and morphologic study of 28 cases. Am J Surg Pathol 1993; 17: 1011–1019.PubMedCrossRefGoogle Scholar
  2. 2.
    Su WPD, Buechner SA, Li C-Y. Clinicopathologic correlations in leukemia cutis. J Am Acad Dermatol 1984; 11: 121–128.PubMedCrossRefGoogle Scholar
  3. 3.
    Stawiski MA. Skin manifestations of leukemias and lymphomas. Cutis 1978; 21: 814–818.PubMedGoogle Scholar
  4. 4.
    Baer MR, Barcos M, Farrell H, Raza A, Preisler HD. Acute myelogenous leukemia with leukemia cutis: Eighteen cases seen between 1969 and 1986. Cancer 1989; 2192–2200.Google Scholar
  5. 5.
    Forjaz de Lacerda J, do Carmo A, Guerra L, Soares de Almeida L, Fernandes A, Forjaz de Lacera JM. Leukemia cutis in acute lymphoblastic leukemia. J Am Acad Dermatol 1994; 30: 1041–1043.PubMedCrossRefGoogle Scholar
  6. 6.
    Long JC, Mihm MC. Multiple granulocytic tumors of the skin: Report of six cases of myelogenous leukemia with initial manifestations in the skin. Cancer 1977; 39: 2004–2016.PubMedCrossRefGoogle Scholar
  7. 7.
    Kaiserling E, Horny H-P, Geerts M-L, Schmid U. Skin involvement in myelogenous leukemia: Morphologic and immunophenotypic heterogeneity of skin infiltrates. Mod Pathol 1994; 7: 771–779.PubMedGoogle Scholar
  8. 8.
    Longacre TA, Smoller BR. Leukemia cutis: Analysis of 50 biopsy-proven cases with an emphasis on occurrence in myelodysplastic syndrome. Am J Clin Pathol 1993; 100: 276–284.PubMedGoogle Scholar
  9. 9.
    Cerroni L, Zenahlik P, Kerl H. Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia arising at the site of herpes zoster and herpes simplex scars. Cancer 1995; 76: 26–31.PubMedCrossRefGoogle Scholar
  10. 10.
    Smoller BR, Warnke RA. Cutaneous infiltrate of chronic lymphocytic leukemia and relationship to primary cutaneous epithelial neoplasms. J Cutan Pathol 1998; 25: 160–164.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Personalised recommendations