Paraneoplastic Pemphigus and Pemphigus Vulgaris


The disease pemphigus encompasses a group of related blistering conditions characterized by circulating antibodies against keratinocyte cell surface antigens important in mediating cell-to-cell adhesion (1,2). Of the various types and forms of the disease including pemphigus foliaceus, pemphigus erythematosus, IgA pemphigus, and pemphigus vegetans, it is pemphigus vulgaris (PV) and paraneoplastic pemphigus (PP) that constitute the most important causes of mortality. Overall, these disorders are quite rare, with an estimated prevalence of between 1 in 100,000 for PV to less than 1 in 1,000,000 for PP. Both disorders are seen principally in aged adults with a near equal gender distribution. PV is more commonly observed among Jews and individuals of Mediterranean descent, whereas there is no known ethnic predilection for PP.


Chronic Lymphocytic Leukemia Lichen Planus Bullous Pemphigoid Blister Formation Mucous Membrane Involvement 
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  1. 1.
    Becker B, Gaspari A. Pemphigus vulgaris and vegetans. Dermatol Clin 1993; 11: 429.PubMedGoogle Scholar
  2. 2.
    Lever W. Pemphigus and pemphigoid. J Am Acad Dermatol 1979; 1: 2.PubMedGoogle Scholar
  3. 3.
    Judd K, Lever W. Correlation of antibodies in skin and serum with disease severity in pemphigus. Arch Dermatol 1979; 115: 428.PubMedCrossRefGoogle Scholar
  4. 4.
    Fellner M, Fukuyama K, Moshell A, et al. Intercellular antibodies in blood and epidermis. Br J Dermatol 1973; 89: 115.PubMedCrossRefGoogle Scholar
  5. 5.
    Joly P, Thomine E, Gilbert D, et al. Overlapping distribution of autoantibody specificities in paraneoplastic pemphigus and pemphigus vulgaris. J Invest Dermatol 1994; 103: 65.PubMedCrossRefGoogle Scholar
  6. 6.
    Pisani M, Ruocco V. Drug-induced pemphigus. Clin Dermatol 1986; 4: 118.PubMedCrossRefGoogle Scholar
  7. 7.
    Ahmed A. Clinical features of pemphigus. Clin Dermatol 1983; 1: 13.PubMedCrossRefGoogle Scholar
  8. 8.
    Meurer M, Milns J, Rogers R, et al. Oral pemphigus vulgaris: A report of ten cases. Arch Dermatol 1977; 113: 1520.PubMedCrossRefGoogle Scholar
  9. 9.
    Camisa C, Helm T. Paraneoplastic pemphigus is a distinct neoplasia-induced autoimmune disease. Arch Dermatol 1993; 129: 883.PubMedCrossRefGoogle Scholar
  10. 10.
    Mutasim D, Pelc N, Anhalt G. Paraneoplastic pemphigus. Dermatol Clin 1993; 11: 473.PubMedCrossRefGoogle Scholar
  11. 11.
    Fried R, Lynfield Y, Vitale P, et al. Paraneoplastic pemphigus appearing as bullous pemphigoid-like eruption after palliative radiation therapy. J Am Acad Dermatol 1993; 29: 815.PubMedGoogle Scholar
  12. 12.
    Tankel M, Tannenbaum S, Parekh S. Paraneoplastic pemphigus presenting as an unusual bullous eruption. J Am Acad Dermatol 1993; 29: 825.PubMedCrossRefGoogle Scholar
  13. 13.
    Rongioletti F, Truchetet F, Rebora A. Paraneoplastic pemphigoid-pemphigus? Subepidermal bullous disease with pemphigus-like direct immunofluorescence. Int J Dermatol 1993; 32: 48.PubMedCrossRefGoogle Scholar
  14. 14.
    Moy R, Jordan R. Immunopathology in pemphigus. Clin Dermatol 1983; 1: 72.PubMedCrossRefGoogle Scholar
  15. 15.
    Ahmed A, May R. Death in pemphigus. J Am Acad Dermatol 1982; 7: 221.PubMedCrossRefGoogle Scholar

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