Eruptive Xanthoma


Eruptive xanthoma (EX) is a serious systemic dyslipidemia with distinctive cutaneous features. Although the dermatologic manifestations are not in themselves serious, their presence may be the harbinger of serious visceral disease. EX is an uncommon disease with a near equal gender incidence, principally seen in two age groups with different predisposing factors. Among children and young adults genetic disturbances in lipid metabolism are largely responsible and include lipoprotein lipase deficiency and Type I and V hyperlipoproteinemia (1). In older adults, acute ethanol ingestion and endocrinologic disturbances including hypothyroidism and diabetes mellitus are often observed. Common to these clinical settings is the presence of serum hypertriglyceridemia and/or elevated very low-density lipoproteins (VLDL) (2). Triglycerides are transported in the serum as a composite, known as a chylomicron, consisting of lipid with the apolipoproteins B-48, C-II, C-III, E, A-I, and A-IV. The apolipoproteins are critical in the metabolism of the chylomicrons. Chylomicrons are synthesized in the intestine and circulate in the serum, passing off triglycerides to the peripheral tissue endothelial capillaries via the enzymatic action of lipoprotein lipase and the binding of apolipoprotein C-II.


Acute Pancreatitis Foam Cell Lipoprotein Lipase Granuloma Annulare Dermatologic Manifestation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Parker F. Xanthomas and hyperlipidemias. J Am Acad Dermatol 1985; 13: 1.PubMedCrossRefGoogle Scholar
  2. 2.
    Parker F. The hyperlipidemias. In BH Thiers, RL Dobson (eds.), Pathogenesis of Skin Diseases. New York: Churchill Livingstone, 1986, 358–362.Google Scholar
  3. 3.
    Maher-Wiese V, Marmer E, Grant-Kels J. Xanthomas and the inherited hyperlipoproteinemias in children and adolescents. Pediatr Dermatol 1990; 7: 166.PubMedGoogle Scholar
  4. 4.
    Barr R, Fujita W, Graham J. Eruptive xanthomas associated with intravenous miconazole. Arch Dermatol 1978; 114: 1544.PubMedCrossRefGoogle Scholar
  5. 5.
    Dicken C, Connolly S. Eruptive xanthomas associated with isotretinoin. Arch Dermatol 1980; 116: 951.PubMedCrossRefGoogle Scholar
  6. 6.
    Jaber P, Wilson B, Johns D, et al. Eruptive xanthomas during pregnancy. J Am Acad Dermatol 1992; 27: 300.PubMedCrossRefGoogle Scholar
  7. 7.
    Archer C, MacDonald D. Eruptive xanthomata in Type V hyperlipoproteinemia associated with diabetes mellitus. Clin Exp Dermatol 1984; 9: 312.PubMedCrossRefGoogle Scholar
  8. 8.
    Brunzell J, Bierman E. Chylomicronemia syndrome. Med Clin North Am 1982; 66: 455.PubMedGoogle Scholar
  9. 9.
    Vermeer B, Van Gent C, Goslings B, et al. Xanthomato sis and other clinical findings with elevated levels of very low density lipoproteins. Br J Dermatol 1979; 100: 657.PubMedCrossRefGoogle Scholar
  10. 10.
    Cooper P. Eruptive xanthoma: A microscopic simulant of granuloma annulare. J Cutan Pathol 1986; 13: 207.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Personalised recommendations