Abstract
Scleromyxedema is a cutaneous condition that is associated with paraproteinemia in more than 80% of cases (1). In the vast majority of cases, the paraprotein is an IgG heavy chain and a γ light chain. Rare cases of к light chains have been reported, and polyclonal hypergammopathy is also seen in some cases. It has been reported that only 10% of patients with scleromyxedema and associated monoclonal gammopathy will progress to multiple myeloma (1). Overall, scleromyxedema is associated with an increased mortality rate, probably due to the manifold systemic associations.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Dineen AM, Dicken CH. Scleromyxedema. J Am Acad Dermatol 1995; 33: 37–43.
Alberts AS, Schulz EJ, Falkson G, Simson IW, Coccia-Portugal MA. Normalization of skin appearance in a patient with scleromyxedema after intensive chemotherapy for Hodgkin’s disease. Dermatologica 1989; 178: 221–224.
Webster GF, Matsuoka LY, Burchmore D. The association of potentially lethal neurologic syndromes with scleromyxedema (popular mucinosis). J Am Acad Dermatol 1993; 28: 105–108.
Rongioletti F, Rebora A. Updated classification of popular mucinosis, lichen myxedematosus, and scleromyxedema. J Am Acad Dermatol 2001; 44: 273–281.
Gabriel SE, Perry HO, Oleson GB, Bowles CA. Scleromyxedema: A scleroderma-like disorder with systemic manifestations. Medicine (Baltimore) 1988: 67: 58–65.
Gottron HA. Skleromyxedema. Arch Dermatol Syphilol 1954; 199: 71–91.
Chanda JJ. Scleromyxedema. Cutis 1979; 24: 549–552.
Rights and permissions
Copyright information
© 2007 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
(2007). Scleromyxedema. In: Deadly Dermatologic Diseases. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68858-9_22
Download citation
DOI: https://doi.org/10.1007/978-0-387-68858-9_22
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-25442-5
Online ISBN: 978-0-387-68858-9
eBook Packages: MedicineMedicine (R0)