Cutaneous B-cell lymphoma is not a single disease, but rather a family of neoplastic processes characterized by a proliferation of malignant B lymphocytes. These lymphomas may arise de novo on the skin (primary cutaneous B cell lymphoma) or spread to the skin as part of a systemic disease (secondary cutaneous B-cell lymphoma). It is not possible to make this distinction based purely on histologic findings, and a systemic work-up is required in all of these patients in order to determine the extent of disease. The prognosis is greatly altered depending upon this extent. As subtypes of lymphoma correlate with clinical correlation, histologic findings, and prognosis, several of the most prevalent subtypes will be described individually.
KeywordsMarginal Zone Lymphoma Reactive Germinal Center Light Chain Restriction Intravascular Lymphoma Neoplastic Follicle
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