Abstract
Cutaneous B-cell lymphoma is not a single disease, but rather a family of neoplastic processes characterized by a proliferation of malignant B lymphocytes. These lymphomas may arise de novo on the skin (primary cutaneous B cell lymphoma) or spread to the skin as part of a systemic disease (secondary cutaneous B-cell lymphoma). It is not possible to make this distinction based purely on histologic findings, and a systemic work-up is required in all of these patients in order to determine the extent of disease. The prognosis is greatly altered depending upon this extent. As subtypes of lymphoma correlate with clinical correlation, histologic findings, and prognosis, several of the most prevalent subtypes will be described individually.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cerroni L, Signoretti S, Hofler G, Annessi G, Putz B, Lackinger E, Metze D, Giannetti A, Kerl H. Primary cutaneous marginal zone B-cell lymphoma: A recently described entity of low-grade malignant cutaneous B-cell lymphoma. Am J Surg Pathol 1997; 21: 1307–1315.
Tomaszewski M-M, Abbondanzo SL, Lupton GL. Extranodal marginal zone B-cell lymphoma of the skin: A morphologic and immunophenotypic study of 11 cases. Am J Dermatopathol 2000; 22: 205–211.
Cerroni L, Kerl H. Cutaneous follicle center cell lymphoma, follicular type. Am J Dermatopathol 2001; 23: 370–373.
Cerroni L, Volkenandy M, Rieger E, Soyer HP, Kerl H. bcl-2 protein expression and correlation with the interchromosomal 14:18 translocation in cutaneous lymphomas and pseudolymphomas. J Invest Dermatol 1994; 102: 231–235.
Rijlaarsdam JU, Toonstra J, Meijer OWM, Noordijk EM, Willemze R. Treatment of primary cutaneous B-cell lymphomas of follicular center cell origin. J Clin Oncol 1996; 14: 549–555.
Vermeer MH, Geelen FAMJ, van Haselen CW, van Voorst Vader PC, Geerts M-L, van Vloten WA, Willemze R (for the Dutch Lymphoma Working Group). Primary cutaneous large B-cell lymphomas of the legs. Arch Dermatol 1996; 132: 1304–1308.
Goodlad JR, Krajewski AS, Batstone PJ, McKy P, White JM, Benton EC, Kavanagh GM, Lucraft HH (on behalf of the Scotland and Newcastle Lymphoma Group). Primary cutaneous diffuse large B-cell lymphoma: Prognostic significance of clinicopathological subtypes. Am J Surg Pathol 2003; 27: 1538–1545.
Bhawan J, Wolff SM, Ucci AA, Bhan AK. Malignant lymphoma and malignant angioendotheliomatosis: One disease. Cancer 1985; 55: 570–576.
Wick MR, Mills SE, Sheithauer BW, Cooper PH, Davitz MA, Parkinson K. Reassessment of malignant “angioendotheliomatosis”: Evidence in favor of its reclassification as “intravascular lymphomatosis.” Am J Surg Pathol 1986; 10: 112–123.
Sangueza O, Hyder DM, Sangueza P. Intravascular lymphomatosis: Report of an unusual case with T cell phenotype occurring in an adolescent male. J Cutan Pathol 1992; 19: 226–231.
Sepp N, Schuler G, Romani N, Geissler D, Gattringer C, Burg G, Bartram CR, Fritsch P. “Intravascular lymphomatosis” (angioendotheliomatosis): Evidence for a T-cell origin in two cases. Hum Pathol 1990: 20: 1051–1058.
Rights and permissions
Copyright information
© 2007 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
(2007). Cutaneous B-Cell Lymphoma. In: Deadly Dermatologic Diseases. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68858-9_2
Download citation
DOI: https://doi.org/10.1007/978-0-387-68858-9_2
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-25442-5
Online ISBN: 978-0-387-68858-9
eBook Packages: MedicineMedicine (R0)