Gardner Syndrome


Gardner syndrome is a variant of familial adenomatous polyposis, an autosomal dominant disease characterized by multiple adenomatous polyps of the colon that inevitably transform into adenocarcinoma, usually by the fifth decade. Some cases are the result of spontaneous mutations. In 1951, Gardner described a familial adenomatous polyposis kindred with extracolonic manifestations, including bone tumors, and soft “cyst-like” surface tumors (1). Interestingly, the cutaneous lesions were not characterized in that report because one family member had expired shortly after having a cutaneous lesion removed, and others in the family were afraid they would meet the same fate if their lesions were removed.


Familial Adenomatous Polyposis Adenomatous Polyposis Coli Familial Adenomatous Polyposis Patient Adenomatous Polyposis Coli Gene Adenomatous Polyposis Coli Mutation 
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