Amyloidosis: Systemic, Nodular, and Epidermal Derived


The amyloidoses encompass a broad category of cutaneous and systemic disorders with important pathogenic consequences. These derive from the direct deposition of abnormal proteins or indirectly relate to potentially deadly systemic disorders that produce such deposits. Each of the amyloidoses can be defined by certain histomorphologic and chemical properties that permit their identification and inclusion into disease categories (1). These designations can be loosely grouped into systemic and cutaneous delimited forms.


Familial Mediterranean Fever Carpal Tunnel Syndrome Amyloid Deposit Methyl Violet Systemic Amyloidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Breathnach S. Amyloid and amyloidosis. JAAD 1988; 18: 1.Google Scholar
  2. 2.
    Tan S, Pepys M. The amyloidosis. Histopathology 1994; 25: 403.PubMedCrossRefGoogle Scholar
  3. 3.
    Wright J. Clinico-pathologic differentiation of common amyloid syndromes. Medicine 1981; 69: 429.CrossRefGoogle Scholar
  4. 4.
    Brownstein M, Helwig E. The cutaneous amyloidoses: localized forms. Arch Dermatol 1970; 102: 8.PubMedCrossRefGoogle Scholar
  5. 5.
    Ratz J, Bailin P. Cutaneous amyloidosis. JAAD 1981; 4: 21.Google Scholar
  6. 6.
    Hashimoto K. Diseases of amyloid, colloid, and hyaline. J Cutan Pathol 1985; 12: 322.PubMedCrossRefGoogle Scholar
  7. 7.
    Lee D, Huang C, Wong C. Dermatopathologic findings in 20 cases of systemic amyloidosis. Am J Dermatopathol 1998; 20: 438.PubMedCrossRefGoogle Scholar
  8. 8.
    Noren P, Westermark P, Cornwell G, et al. Immunofluorescence and histochemical studies of localized cutaneous amyloidosis. Br J Dermatol 1983; 108: 277.PubMedCrossRefGoogle Scholar
  9. 9.
    Breathnach S, Bhogal B, Dyck R, et al. Immunohistochemical demonstration of amyloid P component in skin of normal subjects and patients with cutaneous amyloidosis. Br J Dermatol 1981; 105: 115.PubMedCrossRefGoogle Scholar
  10. 10.
    Kobayashi H, Hashimoto K. Amyloidogenesis in organ-limited cutaneous amyloidosis: An antigenic identity between epidermal keratin and skin amyloid. J Invest Dermatol 1983; 80: 66.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Personalised recommendations