Muir-Torre Syndrome


Sebaceous adenomas are benign adnexal tumors that have no malignant potential. They are of no clinical significance in isolation, but may be indicators of internal malignancy when occurring as part of the Muir-Torre syndrome. Sebaceous adenomas grow as exophytic, yellowish papules and nodules. In most cases, these lesions are less than 1 cm in diameter (1). While they may occur at any body site, they are most common on the face. They usually appear in middle age. Ulceration is not a common feature.


Sebaceous Carcinoma Basaloid Cell Internal Malignancy Visceral Malignancy Sebaceous Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Rulon DB, Helwig EB. Cutaneous sebaceous neoplasms. Cancer 1974; 33:82–102.PubMedCrossRefGoogle Scholar
  2. 2.
    Schartz RA. The Muir-Torre syndrome: A 25-year retrospective. J Am Acad Dermatol 1995; 33:90–104.CrossRefGoogle Scholar
  3. 3.
    Cohen PR, Kohn SR, Kurzrock R. Association of sebaceous gland tumors and internal malignancy: The Muir-Torre syndrome. Am J Med 1991; 90:606–613.PubMedGoogle Scholar
  4. 4.
    Akhtar S, Oza KK, Khan SA, Wright J. Muir-Torre syndrome: Case report of a patient with concurrent jejunal and ureteral cancer and a review of the literature. J Am Acad Dermatol 1999; 41:681–686.PubMedCrossRefGoogle Scholar
  5. 5.
    Nystrom-Lahti M, Parsons R, Sistonen P, Pylkkanen L, Aaltonen LA, Leach FS, Hamilton SR, Watson P, Bronsen E., Fusar, R, et al. Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage. Am J Human Genet 1994; 55:659–665.Google Scholar
  6. 6.
    Mathiak M, Rutten A, Mangold E, Fischer H-P, Ruzicka T, Friedl W, Propping P, Kruse R. Loss of DNA mismatch repair proteins in skin tumors from patients with Muir-Torre syndrome and MSH2 or MLH1 germline mutations: Establishment of immunohistochemical analysis as a screening test. Am J Surg Pathol 2002; 26:338–343.PubMedCrossRefGoogle Scholar
  7. 7.
    Troy JL, Ackerman AB. Sebaceoma. A distinctive benign neoplasm of adnexal epithelium differentiating toward sebaceous cells. Am J Dermatopathol 1984; 6:7–13.PubMedGoogle Scholar
  8. 8.
    Hodek E, Jones RE, Ackerman AB. Solitary keratoacanthoma is a squamous-cell carcinoma: Three examples with metastases. Am J Dermatopathol 1993; 15: 332–342.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Personalised recommendations