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Structure Prediction of Membrane Proteins

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Computational Methods for Protein Structure Prediction and Modeling

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Membrane proteins play a central role in many cellular and physiological processes. It is estimated that integral membrane proteins make up about 20–30% of the proteome (Krogh et al., 2001b; Stevens and Arkin, 2000; von Heijne, 1999). They are essential mediators of material and information transfer across cell membranes. Their functions include active and passive transport of molecules into and out of cells and organelles; transduction of energy among various forms (light, electrical, and chemical energy); as well as reception and transduction of chemical and electrical signals across membranes (Avdonin, 2005; Bockaert et al., 2002; Pahl, 1999; Rehling et al., 2004; Stack et al., 1995). Identifying these transmembrane (TM) proteins and deciphering their molecular mechanisms, then, is of great importance, particularly as applied to biomedicine. Membrane proteins are the targets of a large number of pharmacologically and toxicologically active substances, and are directly involved in their uptake, metabolism, and clearance (Bettler et al., 1998; Cohen, 2002; Heusser and Jardieu, 1997; Tibes et al., 2005; Xu et al., 2005). Despite the importance of membrane proteins, the knowledge of their high-resolution structures and mechanisms of action has lagged far behind in comparison to that of water-soluble proteins: less than 1% of all three-dimensional structures deposited in the Protein Data Bank are of membrane proteins. This unfortunate disparity stems from difficulties in overexpression and the crystallization of membrane proteins (Grisshammer and Tate, 1995; Michel, 1991).

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Authors and Affiliations

  1. Department of Chemistry, University of Toledo, Toledo, Ohio, 43606

    Xiche Hu

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  1. Xiche Hu
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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Georgia, 120 Green Street, Athens, GA, 30602, USA

    Ying Xu

  2. Department of Computer Science Digital Biology Laboratory, University of Missouri—Columbia, 201 Engineering Building, West Columbia, MO, 65211, USA

    Dong Xu

  3. Department of Bioengineering Center for Bioinformatics, University of Illinois at Chicago, 851 S. Morgan Street, Chicago, IL, 60607-063, USA

    Jie Liang

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Hu, X. (2007). Structure Prediction of Membrane Proteins. In: Xu, Y., Xu, D., Liang, J. (eds) Computational Methods for Protein Structure Prediction and Modeling. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68825-1_3

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