Transplantation Pathology

  • Dani S. Zander


As solid organ and hematopoietic cell transplantation have evolved from experimental procedures to accepted approaches to therapy for many disorders, experience in recognizing transplantation-associated complications has also grown. The lung is a common site of involvement by many of these complications, in some cases representing the primary organ affected and in others serving as one site of many affected by a systemic disease process. The roster of potential complications to which transplant patients are subject varies depending on the type of transplantation performed, the nature of the underlying disorder that made transplantation necessary, other concurrent disease processes that may exist, the nature and intensity of immunosuppressive therapies and other treatments that may also be selected, and a wide variety of immunologic, physical, and metabolic factors that are becoming increasingly recognized with time.


Transplant Recipient Human Leukocyte Antigen Acute Rejection Lung Transplant Respir Crit 
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  1. 1.
    Hardy JD, Webb WR, Dalton ML Jr, Walker GR Jr. Lung homotransplantation in man. JAMA 1963;186:1065–1074.PubMedCrossRefGoogle Scholar
  2. 2.
    Reitz BA, Wallwork JL, Hunt SA, et al. Heart-lung transplantation: successful therapy for patients with pulmonary vascular disease. N Engl J Med 1982;306:557–564.PubMedCrossRefGoogle Scholar
  3. 3.
    Unilateral lung transplantation for pulmonary fibrosis. Toronto Lung Transplant Group. N Engl J Med 1986;314:1140–1145.Google Scholar
  4. 4.
    Patterson GA, Cooper JD, Goldman B, et al. Technique of successful clinical double-lung transplantation. Ann Thorac Surg 1988;45:626–633.PubMedCrossRefGoogle Scholar
  5. 5.
    Trulock EP, Edwards LB, Taylor DO, Boucek MM, Keck BM, Hertz MI. The Registry of the International Society for Heart and Lung Transplantation: twenty-first official adult heart transplant report-2004. J Heart Lung Transplant 2004;23:804–815.PubMedCrossRefGoogle Scholar
  6. 6.
    Boucek MM, Edwards LB, Keck BM, Trulock EP, Taylor DO, Hertz MI. Registry for the International Society for Heart and Lung Transplantation: seventh official pediatric report-2004. J Heart Lung Transplant 2004;23:933–947.PubMedCrossRefGoogle Scholar
  7. 7.
    Veeken C, Palmer SM, Davis RD, Grichnik KP. Living-related lobar lung transplantation. J Cardiothorac Vasc Anesth 2004;18:506–511.PubMedCrossRefGoogle Scholar
  8. 8.
    Starnes VA, Woo MS, MacLaughlin EF, et al. Comparison of outcomes between living donor and cadaveric lung transplantation in children. Ann Thorac Surg 1999;68:2279–2283.PubMedCrossRefGoogle Scholar
  9. 9.
    Nizami I, Frost AE. Clinical diagnosis of transplant-related problems. In: Cagle PT, ed. Diagnostic pulmonary pathology. New York: Marcel Dekker, 2000:485–499.Google Scholar
  10. 10.
    Kundu S, Herman SJ, Larhs A, et al. Correlation of chest radiographic findings with biopsy-proven acute lung rejection. J Thorac Imaging 1999;14:178–184.PubMedCrossRefGoogle Scholar
  11. 11.
    Higenbottam T, Stewart S, Penketh A, Wallwork J. Transbronchial lung biopsy for the diagnosis of rejection in heart-lung transplant patients. Transplantation 1988;46:532–539.PubMedCrossRefGoogle Scholar
  12. 12.
    Trulock EP. Flexible bronchoscopy in lung transplantation. Clin Chest Med 1999;20:77–87.PubMedCrossRefGoogle Scholar
  13. 13.
    Kukafka DS, O’Brien GM, Furukawa S, Criner GJ. Surveillance bronchoscopy in lung transplant recipients. Chest 1997;111:377–381.PubMedCrossRefGoogle Scholar
  14. 14.
    Chakinala MM, Trulock EP. Acute allograft rejection after lung transplantation: diagnosis and therapy. Chest Surg Clin North Am 2003;13:525–542.CrossRefGoogle Scholar
  15. 15.
    Dransfield MT, Garver RI, Weill D. Standardized guidelines for surveillance bronchoscopy reduce complications in lung transplant recipients. J Heart Lung Transplant 2004;23:110–114.PubMedCrossRefGoogle Scholar
  16. 16.
    Bando K, Paradis IL, Similo S, et al. Obliterative bronchiolitis after lung and heart-lung transplantation. An analysis of risk factors and management. J Thorac Cardiovasc Surg 1995;110:4–13.PubMedCrossRefGoogle Scholar
  17. 17.
    Swanson SJ, Mentzer SJ, Reilly JJ, et al. Surveillance transbronchial lung biopsies: implication for survival after lung transplantation. J Thorac Cardiovasc Surg 2000;119:27–37.PubMedCrossRefGoogle Scholar
  18. 18.
    Valentine VG, Taylor DE, Dhillon GS, et al. Success of lung transplantation without surveillance bronchoscopy. J Heart Lung Transplant 2002;21:319–326.PubMedCrossRefGoogle Scholar
  19. 19.
    Yousem SA, Berry GJ, Cagle PT, et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group. J Heart Lung Transplant 1996;15:1–15.PubMedGoogle Scholar
  20. 20.
    Arbustini E, Morbini P, Grasso M, et al. Human cytomegalovirus early infection, acute rejection, and major histocompatibility class II expression in transplanted lung. Molecular, immunocytochemical, and histopathologic investigations. Transplantation 1996;61:418–427.PubMedCrossRefGoogle Scholar
  21. 21.
    Christie JD, Carby M, Bag R, Corris P, Hertz M, Weill D. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 2005;24:1454–1459.PubMedCrossRefGoogle Scholar
  22. 22.
    Christie JD, Bavaria JE, Palevsky HI, et al. Primary graft failure following lung transplantation. Chest 1998;114:51–60.PubMedCrossRefGoogle Scholar
  23. 23.
    Christie JD, Kotloff RM, Pochettino A, et al. Clinical risk factors for primary graft failure following lung transplantation. Chest 2003;124:1232–1241.PubMedCrossRefGoogle Scholar
  24. 24.
    Thabut G, Vinatier I, Stern JB, et al. Primary graft failure following lung transplantation: predictive factors of mortality. Chest 2002;121:1876–1882.PubMedCrossRefGoogle Scholar
  25. 25.
    Sleiman C, Mai H, Fournier M, et al. Pulmonary reimplantation response in single-lung transplantation. Eur Respir J 1995;8:5–9.PubMedCrossRefGoogle Scholar
  26. 26.
    De Perrot M, Liu M, Waddell TK, Keshavjee S. Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 2003;167:490–511.PubMedCrossRefGoogle Scholar
  27. 27.
    Unruh HW. Lung preservation and lung injury. Chest Surg Clin North Am 1995;5:91–106.Google Scholar
  28. 28.
    Serrick C, Adoumie R, Giaid A, Shennib H. The early release of interleukin-2, tumor necrosis factor-alpha and interferon-gamma after ischemia reperfusion injury in the lung allograft. Transplantation 1994;58:1158–1162.PubMedGoogle Scholar
  29. 29.
    De Perrot M, Sekine Y, Fischer S, et al. Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation. Am J Respir Crit Care Med 2002;165:211–215.PubMedCrossRefGoogle Scholar
  30. 30.
    Shennib H, Serrick C, Saleh D, Adoumie R, Stewart DJ, Giaid A. Alterations in bronchoalveolar lavage and plasma endothelin-1 levels early after lung transplantation. Transplantation 1995;59:994–998.PubMedCrossRefGoogle Scholar
  31. 31.
    Abraham D, Taghavi S, Riml P, et al. VEGF-A and-C but not-B mediate increased vascular permeability in preserved lung grafts. Transplantation 2002;73:1703–1706.PubMedCrossRefGoogle Scholar
  32. 32.
    Ciulli F, Tamm M, Dennis C, et al. Donor-transmitted bacterial infection in heart-lung transplantation. Transplant Proc 1993;25:1155–1156.PubMedGoogle Scholar
  33. 33.
    Jones SD, Fullerton DA, Zamora MR, Badesch DB, Campbell DN, Grover FL. Transmission of Lactobacillus pneumonia by a transplanted lung. Ann Thorac Surg 1994;58:887–889.PubMedCrossRefGoogle Scholar
  34. 34.
    Koutlas TC, Bridges ND, Gaynor JW, Nicolson SC, Steven JM, Spray TL. Pediatric lung transplantation—are there surgical contraindications? Transplantation 1997;63:269–274.PubMedCrossRefGoogle Scholar
  35. 35.
    Bridges ND, Spray TL, Collins MH, Bowles NE, Towbin JA. Adenovirus infection in the lung results in graft failure after lung transplantation. J Thorac Cardiovasc Surg 1998;116:617–623.PubMedCrossRefGoogle Scholar
  36. 36.
    Haque T, Thomas JA, Falk KI, et al. Transmission of donor Epstein-Barr virus (EBV) in transplanted organs causes lymphoproliferative disease in EBV-seronegative recipients. J Gen Virol 1996;77:1169–1172.PubMedCrossRefGoogle Scholar
  37. 37.
    Kanj SS, Welty-Wolf K, Madden J, et al. Fungal infections in lung and heart-lung transplant recipients. Report of 9 cases and review of the literature. Medicine (Baltimore) 1996;75:142–156.PubMedCrossRefGoogle Scholar
  38. 38.
    Tripathy U, Yung GL, Kriett JM, Thistlethwaite PA, Kapelanski DP, Jamieson SW. Donor transfer of pulmonary coccidioidomycosis in lung transplantation. Ann Thorac Surg 2002;73:306–308.PubMedCrossRefGoogle Scholar
  39. 39.
    Miller MB, Hendren R, Gilligan PH. Posttransplantation disseminated coccidioidomycosis acquired from donor lungs. J Clin Microbiol 2004;42:2347–2349.PubMedCrossRefGoogle Scholar
  40. 40.
    Wreghitt TG, Hakim M, Gray JJ, et al. Toxoplasmosis in heart and heart and lung transplant recipients. J Clin Pathol 1989;42:194–199.PubMedCrossRefGoogle Scholar
  41. 41.
    Couvreur J, Tournier G, Sardet-Frismand A, Fauroux B. Heart or heart-lung transplantation and toxoplasmosis. Presse Med. 1992;21:1569–1574.PubMedGoogle Scholar
  42. 42.
    Ridgeway AL, Warner GS, Phillips P, et al. Transmission of Mycobacterium tuberculosis to recipients of single lung transplants from the same donor. Am J Respir Crit Care Med 1996;153:1166–1168.PubMedCrossRefGoogle Scholar
  43. 43.
    Schulman LL, Scully B, McGregor CC, Austin JH. Pulmonary tuberculosis after lung transplantation. Chest 1997;111:1459–1462.PubMedCrossRefGoogle Scholar
  44. 44.
    Lee J, Yew WW, Wong CF, Wong PC, Chiu CS. Multidrug-resistant tuberculosis in a lung transplant recipient. J Heart Lung Transplant 2003;22:1168–1173.PubMedCrossRefGoogle Scholar
  45. 45.
    Shitrit D, Bendayan D, Saute M, Kramer MR. Multidrug resistant tuberculosis following lung transplantation: treatment with pulmonary resection. Thorax 2004;59:79–80.PubMedGoogle Scholar
  46. 46.
    Date H, Trulock EP, Arcidi JM, Sundaresan S, Cooper JD, Patterson GA. Improved airway healing after lung transplantation. An analysis of 348 bronchial anastomoses. J Thorac Cardiovasc Surg 1995;110:1424–1432.PubMedCrossRefGoogle Scholar
  47. 47.
    Kshettry VR, Kroshus TJ, Hertz MI, Hunter DW, Shumway SJ, Bolman RM. Early and late airway complications after lung transplantation: incidence and management. Ann Thorac Surg 1997;63:1576–1583.PubMedCrossRefGoogle Scholar
  48. 48.
    Kaditis AG, Gondor M, Nixon PA, et al. Airway complications following pediatric lung and heart-lung transplantation. Am J Respir Crit Care Med 2000;162:301–309.PubMedCrossRefGoogle Scholar
  49. 49.
    Alvarez A, Algar J, Santos F, et al. Airway complications after lung transplantation: a review of 151 anastomoses. Eur J Cardiothorac Surg 2001;19:381–387.PubMedCrossRefGoogle Scholar
  50. 50.
    Mulligan MS. Endoscopic management of airway complications after lung transplantation. Chest Surg Clin North Am 2001;11:907–915.Google Scholar
  51. 51.
    Horvath J, Dummer S, Loyd J, Walker B, Merrill WH, Frist WH. Infection in the transplanted and native lung after single lung transplantation. Chest 1993;104:681–685.PubMedCrossRefGoogle Scholar
  52. 52.
    Hadjiliadis D, Howell DN, Davis RD, et al. Anastomotic infections in lung transplant recipients. Ann Transplant 2000;5:13–19.PubMedGoogle Scholar
  53. 53.
    Herrera JM, McNeil KD, Higgins RS, et al. Airway complications after lung transplantation: treatment and long-term outcome. Ann Thorac Surg 2001;71:989–993;discussion 93–94.PubMedCrossRefGoogle Scholar
  54. 54.
    Kramer MR, Denning DW, Marshall SE, et al. Ulcerative tracheobronchitis after lung transplantation. A new form of invasive aspergillosis. Am Rev Respir Dis 1991;144:552–556.PubMedCrossRefGoogle Scholar
  55. 55.
    Sarsam MA, Yonan NA, Beton D, McMaster D, Deiraniya AK. Early pulmonary vein thrombosis after single lung transplantation. J Heart Lung Transplant 1993;12:17–19.PubMedGoogle Scholar
  56. 56.
    Zander DS, Baz MA, Visner GA, et al. Analysis of early deaths after isolated lung transplantation. Chest 2001;120:225–232.PubMedCrossRefGoogle Scholar
  57. 57.
    Liguori C, Schulman LL, Weslow RG, et al. Late pulmonary venous complications after lung transplantation. J Am Soc Echocardiogr 1997;10:763–767.PubMedCrossRefGoogle Scholar
  58. 58.
    Clark SC, Levine AJ, Hasan A, Hilton CJ, Forty J, Dark JH. Vascular complications of lung transplantation. Ann Thorac Surg 1996;61:1079–1082.PubMedCrossRefGoogle Scholar
  59. 59.
    Hearne SE, O’Laughlin MP, Davis RD, Baker WA, Bashore TM, Harrison JK. Total pulmonary artery occlusion immediately after lung transplantation: successful revascularization with intravascular stents. J Heart Lung Transplant 1996;15:532–535.PubMedGoogle Scholar
  60. 60.
    Hausmann D, Daniel WG, Mugge A, et al. Imaging of pulmonary artery and vein anastomoses by transesophageal echocardiography after lung transplantation. Circulation 1992;86:11251–11258.Google Scholar
  61. 61.
    Marques LJ, Teschler H, Guzman J, Costabel U. Smoker’s lung transplanted to a nonsmoker. Long-term detection of smoker’s macrophages. Am J Respir Crit Care Med 1997;156:1700–1702.PubMedCrossRefGoogle Scholar
  62. 62.
    Yousem SA, Berry GJ, Brunt EM, et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Lung Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant 1990;9:593–601.Google Scholar
  63. 63.
    Cooper JD, Billingham M, Egan T, et al. A working formulation for the standardization of nomenclature and for clinical staging of chronic dysfunction in lung allografts. International Society for Heart and Lung Transplantation. J Heart Lung Transplant 1993;12:713–716.PubMedGoogle Scholar
  64. 64.
    Estenne M, Maurer JR, Boehler A, et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant 2002;21:297–310.PubMedCrossRefGoogle Scholar
  65. 65.
    Baz MA, Layish DT, Govert JA, et al. Diagnostic yield of bronchoscopies after isolated lung transplantation. Chest 1996;110:84–88.PubMedCrossRefGoogle Scholar
  66. 66.
    Reichenspurner H, Girgis RE, Robbins RC, et al. Stanford experience with obliterative bronchiolitis after lung and heart-lung transplantation. Ann Thorac Surg 1996;62:1467–1472.PubMedCrossRefGoogle Scholar
  67. 67.
    Girgis RE, Tu I, Berry GJ, et al. Risk factors for the development of obliterative bronchiolitis after lung transplantation. J Heart Lung Transplant 1996;15:1200–1208.PubMedGoogle Scholar
  68. 68.
    Kroshus TJ, Kshettry VR, Savik K, John R, Hertz MI, Bolman RM. Risk factors for the development of bronchiolitis obliterans syndrome after lung transplantation. J Thorac Cardiovasc Surg 1997;114:195–202.PubMedCrossRefGoogle Scholar
  69. 69.
    Heng D, Sharpies LD, McNeil K, Stewart S, Wreghitt T, Wallwork J. Bronchiolitis obliterans syndrome: incidence, natural history, prognosis, and risk factors. J Heart Lung Transplant 1998;17:1255–1263.PubMedGoogle Scholar
  70. 70.
    Husain AN, Siddiqui MT, Holmes EW, et al. Analysis of risk factors for the development of bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 1999;159:829–833.PubMedCrossRefGoogle Scholar
  71. 71.
    Schulman LL, Weinberg AD, McGregor CC, Suciu-Foca NM, Itescu S. Influence of donor and recipient HLA locus mismatching on development of obliterative bronchiolitis after lung transplantation. Am J Respir Crit Care Med 2001;163:437–442.PubMedCrossRefGoogle Scholar
  72. 72.
    Chalermskulrat W, Neuringer IP, Schmitz JL, et al. Human leukocyte antigen mismatches predispose to the severity of bronchiolitis obliterans syndrome after lung transplantation. Chest 2003;123:1825–1831.PubMedCrossRefGoogle Scholar
  73. 73.
    Husain S, Singh N. Bronchiolitis obliterans and lung transplantation: evidence for an infectious etiology. Semin Respir Infect 2002;17:310–314.PubMedCrossRefGoogle Scholar
  74. 74.
    Billings JL, Hertz MI, Savik K, Wendt CH. Respiratory viruses and chronic rejection in lung transplant recipients. J Heart Lung Transplant 2002;21:559–566.PubMedCrossRefGoogle Scholar
  75. 75.
    Vilchez RA, Dauber J, Kusne S. Infectious etiology of bronchiolitis obliterans: the respiratory viruses connection-myth or reality? Am J Transplant 2003;3:245–249.PubMedCrossRefGoogle Scholar
  76. 76.
    Paradis I, Yousem S, Griffith B. Airway obstruction and bronchiolitis obliterans after lung transplantation. Clin Chest Med 1993;14:751–763.PubMedGoogle Scholar
  77. 77.
    Reichenspurner H, Girgis RE, Robbins RC, et al. Obliterative bronchiolitis after lung and heart-lung transplantation. Ann Thorac Surg 1995;60:1845–1853.PubMedCrossRefGoogle Scholar
  78. 78.
    Spector NM, Connolly MA, Garrity ER Jr. Lung transplant rejection: obliterative bronchiolitis. Am J Crit Care 1996;5:366–372.PubMedGoogle Scholar
  79. 79.
    Sundaresan S. Bronchiolitis obliterans. Semin Thorac Cardiovasc Surg 1998;10:221–226.PubMedGoogle Scholar
  80. 80.
    Boehler A, Estenne M. Obliterative bronchiolitis after lung transplantation. Curr Opin Pulm Med 2000;6:133–139.PubMedCrossRefGoogle Scholar
  81. 81.
    Iacono AT, Keenan RJ, Duncan SR, et al. Aerosolized cyclosporine in lung recipients with refractory chronic rejection. Am J Respir Crit Care Med 1996;153:1451–1455.PubMedCrossRefGoogle Scholar
  82. 82.
    Snell GI, Esmore DS, Williams TJ. Cytolytic therapy for the bronchiolitis obliterans syndrome complicating lung transplantation. Chest 1996;109:874–878.PubMedCrossRefGoogle Scholar
  83. 83.
    Dusmet M, Maurer J, Winton T, Kesten S. Methotrexate can halt the progression of bronchiolitis obliterans syndrome in lung transplant recipients. J Heart Lung Transplant 1996;15:948–954.PubMedGoogle Scholar
  84. 84.
    Ross DJ, Lewis MI, Kramer M, Vo A, Kass RM. FK 506 “rescue” immunosuppression for obliterative bronchiolitis after lung transplantation. Chest 1997;112:1175–1179.PubMedCrossRefGoogle Scholar
  85. 85.
    Kesten S, Chaparro C, Scavuzzo M, Gutierrez C. Tacrolimus as rescue therapy for bronchiolitis obliterans syndrome. J Heart Lung Transplant 1997;16:905–912.PubMedGoogle Scholar
  86. 86.
    Date H, Lynch JP, Sundaresan S, Patterson GA, Trulock EP. The impact of cytolytic therapy on bronchiolitis obliterans syndrome. J Heart Lung Transplant 1998;17:869–875.PubMedGoogle Scholar
  87. 87.
    Diamond DA, Michalski JM, Lynch JP, Trulock EP. Efficacy of total lymphoid irradiation for chronic allograft rejection following bilateral lung transplantation. Int J Radiat Oncol Biol Phys 1998;41:795–800.PubMedCrossRefGoogle Scholar
  88. 88.
    Paradis I. Bronchiolitis obliterans: pathogenesis, prevention, and management. Am J Med Sci 1998;315:161–178.PubMedCrossRefGoogle Scholar
  89. 89.
    O’Hagan AR, Stillwell PC, Arroliga A, Koo A. Photopheresis in the treatment of refractory bronchiolitis obliterans complicating lung transplantation. Chest 1999;115:1459–1462.PubMedCrossRefGoogle Scholar
  90. 90.
    Salerno CT, Park SJ, Kreykes NS, et al. Adjuvant treatment of refractory lung transplant rejection with extracorporeal photopheresis. J Thorac Cardiovasc Surg 1999;117:1063–1069.PubMedCrossRefGoogle Scholar
  91. 91.
    Verleden GM, Buyse B, Delcroix M, et al. Cyclophosphamide rescue therapy for chronic rejection after lung transplantation. J Heart Lung Transplant 1999;18:1139–1142.PubMedCrossRefGoogle Scholar
  92. 92.
    Cairn J, Yek T, Banner NR, Khaghani A, Hodson ME, Yacoub M. Time-related changes in pulmonary function after conversion to tacrolimus in bronchiolitis obliterans syndrome. J Heart Lung Transplant 2003;22:50–57.PubMedCrossRefGoogle Scholar
  93. 93.
    Hachem RR, Khalifah AP, Chakinala MM, et al. The significance of a single episode of minimal acute rejection after lung transplantation. Transplantation 2005;80:1406–1413.PubMedCrossRefGoogle Scholar
  94. 94.
    Khalifah AP, Hachem RR, Chakinala MM, et al. Minimal acute rejection after lung transplantation: a risk for bronchiolitis obliterans syndrome. Am J Transplant 2005;5:2022–2030.PubMedCrossRefGoogle Scholar
  95. 95.
    Hopkins PM, Aboyoun CL, Chhajed PN, et al. Association of minimal rejection in lung transplant recipients with obliterative bronchiolitis. Am J Respir Crit Care Med 2004;170:1022–1026.PubMedCrossRefGoogle Scholar
  96. 96.
    Tazelaar HD. Perivascular inflammation in pulmonary infections: implications for the diagnosis of lung rejection. J Heart Lung Transplant 1991;10:437–441.PubMedGoogle Scholar
  97. 97.
    Rosendale B, Yousem SA. Discrimination of Epstein-Barr virus-related posttransplant lymphoproliferations from acute rejection in lung allograft recipients. Arch Pathol Lab Med 1995;119:418–423.PubMedGoogle Scholar
  98. 98.
    Yousem SA. Lymphocytic bronchitis/bronchiolitis in lung allograft recipients. Am J Surg Pathol 1993;17:491–496.PubMedCrossRefGoogle Scholar
  99. 99.
    Badizadegan K, Perez-Atayde AR. Pathology of lung allografts in children and young adults. Hum Pathol 1997;28:704–713.PubMedCrossRefGoogle Scholar
  100. 100.
    Yousem SA. Graft eosinophilia in lung transplantation. Hum Pathol 1992;23:1172–1177.PubMedCrossRefGoogle Scholar
  101. 101.
    Frost AE, Jammal CT, Cagle PT. Hyperacute rejection following lung transplantation. Chest 1996;110:559–562.PubMedCrossRefGoogle Scholar
  102. 102.
    Choi JK, Kearns J, Palevsky HI, et al. Hyperacute rejection of a pulmonary allograft. Immediate clinical and pathologic findings. Am J Respir Crit Care Med 1999;160:1015–1018.PubMedCrossRefGoogle Scholar
  103. 103.
    Scornik JC, Zander DS, Baz MA, Donnelly WH, Staples ED. Susceptibility of lung transplants to preformed donor-specific HLA antibodies as detected by flow cytometry. Transplantation 1999;68:1542–1546.PubMedCrossRefGoogle Scholar
  104. 104.
    Bittner HB, Dunitz J, Hertz M, Bolman MR, 3rd, Park SJ. Hyperacute rejection in single lung transplantation—case report of successful management by means of plasmapheresis and antithymocyte globulin treatment. Transplantation 2001;71:649–651.PubMedCrossRefGoogle Scholar
  105. 105.
    Takemoto SK, Zeevi A, Feng S, et al. National conference to assess antibody-mediated rejection in solid organ transplantation. Am J Transplant 2004;4:1033–1041.PubMedCrossRefGoogle Scholar
  106. 106.
    Yousem SA, Curley JM, Dauber J, et al. HLA-class II antigen expression in human heart-lung allografts. Transplantation 1990;49:991–995.PubMedCrossRefGoogle Scholar
  107. 107.
    Milne DS, Gascoigne AD, Wilkes J, et al. MHC class II and ICAM-1 expression and lymphocyte subsets in transbronchial biopsies from lung transplant recipients. Transplantation 1994;57:1762–1766.PubMedGoogle Scholar
  108. 108.
    Devouassoux G, Pison C, Drouet C, Pin I, Brambilla C, Brambilla E. Early lung leukocyte infiltration, HLA and adhesion molecule expression predict chronic rejection. Transplant Immunol 2001;8:229–236.CrossRefGoogle Scholar
  109. 109.
    Reinsmoen NL, Nelson K, Zeevi A. Anti-HLA antibody analysis and crossmatching in heart and lung transplantation. Transplant Immunol 2004;13:63–71.CrossRefGoogle Scholar
  110. 110.
    Sundaresan S, Mohanakumar T, Smith MA, et al. HLA-A locus mismatches and development of antibodies to HLA after lung transplantation correlate with the development of bronchiolitis obliterans syndrome. Transplantation 1998;65:648–653.PubMedCrossRefGoogle Scholar
  111. 111.
    Girnita AL, McCurry KR, Iacono AT, et al. HLA-Specific antibodies are associated with high-grade and persistent-recurrent lung allograft acute rejection. J Heart Lung Transplant 2004;23:1135–1141.PubMedCrossRefGoogle Scholar
  112. 112.
    Badesch DB, Zamora M, Fullerton D, et al. Pulmonary capillaritis: a possible histologic form of acute pulmonary allograft rejection. J Heart Lung Transplant 1998;17:415–422.PubMedGoogle Scholar
  113. 113.
    Magro CM, Deng A, Pope-Harman A, et al. Humorally mediated posttransplantation septal capillary injury syndrome as a common form of pulmonary allograft rejection: a hypothesis. Transplantation 2002;74:1273–1280.PubMedCrossRefGoogle Scholar
  114. 114.
    Magro CM, Ross P Jr, Kelsey M, Waldman WJ, Pope-Harman A. Association of humoral immunity and bronchiolitis obliterans syndrome. Am J Transplant 2003;3:1155–1166.PubMedCrossRefGoogle Scholar
  115. 115.
    Ionescu DN, Girnita AL, Zeevi A, et al. C4d deposition in lung allografts is associated with circulating anti-HLA alloantibody. Transplant Immunol 2005;15:63–68.CrossRefGoogle Scholar
  116. 116.
    Wallace WD, Reed EF, Ross D, Lassman CR, Fishbein MC. C4d staining of pulmonary allograft biopsies: an immunoperoxidase study. J Heart Lung Transplant 2005;24:1565–1570.PubMedCrossRefGoogle Scholar
  117. 117.
    Miller GG, Destarac L, Zeevi A, et al. Acute humoral rejection of human lung allografts and elevation of C4d in bronchoalveolar lavage fluid. Am J Transplant 2004;4:1323–1330.PubMedCrossRefGoogle Scholar
  118. 118.
    Michaels PJ, Fishbein MC, Colvin RB. Humoral rejection of human organ transplants. Springer Semin Immunopathol 2003;25:119–140.PubMedCrossRefGoogle Scholar
  119. 119.
    Jaramillo A, Fernandez FG, Kuo EY, Trulock EP, Patterson GA, Mohanakumar T. Immune mechanisms in the pathogenesis of bronchiolitis obliterans syndrome after lung transplantation. Pediatr Transplant 2005;9:84–93.PubMedCrossRefGoogle Scholar
  120. 120.
    Reinsmoen NL, Bolman RM, Savik K, Butters K, Hertz M. Differentiation of class I-and class Il-directed donor-specific alloreactivity in bronchoalveolar lavage lymphocytes from lung transplant recipients. Transplantation 1992;53:181–189.PubMedCrossRefGoogle Scholar
  121. 121.
    Rogers NJ, Leckler RI. Allorecognition. Am J Transplant 2001;1:97–102.PubMedCrossRefGoogle Scholar
  122. 122.
    Heeger PS. T cell allorecognition and transplant rejection: a summary and update. Am J Transplant 2003;3:525–533.PubMedCrossRefGoogle Scholar
  123. 123.
    Stanford RE, Ahmed S, Hodson M, Banner NR, Rose ML. A role for indirect allorecognition in lung transplant recipients with obliterative bronchiolitis. Am J Transplant 2003;3:736–742.PubMedCrossRefGoogle Scholar
  124. 124.
    Taylor PM, Rose ML, Yacoub MH. Expression of MHC antigens in normal human lungs and transplanted lungs with obliterative bronchiolitis. Transplantation 1989;48:506–510.PubMedCrossRefGoogle Scholar
  125. 125.
    Mauck KA, Hosenpud JD. The bronchial epithelium: a potential allogeneic target for chronic rejection after lung transplantation. J Heart Lung Transplant 1996;15:709–714.PubMedGoogle Scholar
  126. 126.
    Smith CR, Jaramillo A, Duffy BF, Mohanakumar T. Airway epithelial cell damage mediated by antigen-specific T cells: implications in lung allograft rejection. Hum Immunol 2000;61:985–992.PubMedCrossRefGoogle Scholar
  127. 127.
    Hasegawa S, Ockner DM, Ritter JH, et al. Expression of class II major histocompatibility complex antigens (HLA-DR) and lymphocyte subset immunotyping in chronic pulmonary transplant rejection. Arch Pathol Lab Med 1995;119:432–439.PubMedGoogle Scholar
  128. 128.
    Duncan SR, Leonard C, Theodore J, et al. Oligoclonal CD4(+) T cell expansions in lung transplant recipients with obliterative bronchiolitis. Am J Respir Crit Care Med 2002;165:1439–1444.PubMedCrossRefGoogle Scholar
  129. 129.
    Lu KC, Jaramillo A, Mendeloff EN, et al. Concomitant allorecognition of mismatched donor HLA class I-and class Il-derived peptides in pediatric lung transplant recipients with bronchiolitis obliterans syndrome. J Heart Lung Transplant 2003;22:35–43.PubMedCrossRefGoogle Scholar
  130. 130.
    SivaSai KS, Smith MA, Poindexter NJ, et al. Indirect recognition of donor HLA class I peptides in lung transplant recipients with bronchiolitis obliterans syndrome. Transplantation 1999;67:1094–1098.PubMedCrossRefGoogle Scholar
  131. 131.
    Reznik SI, Jaramillo A, SivaSai KS, et al. Indirect allorecognition of mismatched donor HLA class II peptides in lung transplant recipients with bronchiolitis obliterans syndrome. Am J Transplant 2001;1:228–235.PubMedCrossRefGoogle Scholar
  132. 132.
    Smith MA, Sundaresan S, Mohanakumar T, et al. Effect of development of antibodies to HLA and cytomegalovirus mismatch on lung transplantation survival and development of bronchiolitis obliterans syndrome. J Thorac Cardiovasc Surg 1998;116:812–820.PubMedCrossRefGoogle Scholar
  133. 133.
    Jaramillo A, Smith MA, Phelan D, et al. Development of ELISA-detected anti-HLA antibodies precedes the development of bronchiolitis obliterans syndrome and correlates with progressive decline in pulmonary function after lung transplantation. Transplantation 1999;67:1155–1161.PubMedCrossRefGoogle Scholar
  134. 134.
    Palmer SM, Davis RD, Hadjiliadis D, et al. Development of an antibody specific to major histocompatibility antigens detectable by flow cytometry after lung transplant is associated with bronchiolitis obliterans syndrome. Transplantation 2002;74:799–804.PubMedCrossRefGoogle Scholar
  135. 135.
    Jaramillo A, Smith CR, Zhang L, Patterson GA, Mohanakumar T. Anti-HLA antibody binding to HLA class I molecules induces production of fibrogenic growth factors and apoptotic cell death: a possible mechanism for bronchiolitis obliterans syndrome. Hum Immunol 2003;64:521–529.PubMedCrossRefGoogle Scholar
  136. 136.
    Hansen PR, Holm AM, Svendsen UG, Olsen PS, Andersen CB. Apoptosis and formation of peroxynitrite in the lungs of patients with obliterative bronchiolitis. J Heart Lung Transplant 2000;19:160–166.PubMedCrossRefGoogle Scholar
  137. 137.
    Jaramillo A, Naziruddin B, Zhang L, et al. Activation of human airway epithelial cells by non-HLA antibodies developed after lung transplantation: a potential etiological factor for bronchiolitis obliterans syndrome. Transplantation 2001;71:966–976.PubMedCrossRefGoogle Scholar
  138. 138.
    Riise GC, Andersson BA, Kjellstrom C, et al. Persistent high BAL fluid granulocyte activation marker levels as early indicators of bronchiolitis obliterans after lung transplant. Eur Respir J 1999;14:1123–1130.PubMedCrossRefGoogle Scholar
  139. 139.
    Riise GC. On interleukin-8, neutrophil activation, and bronchiolitis obliterans syndrome in lung transplantation. Transplantation 2000;70:265–266.PubMedCrossRefGoogle Scholar
  140. 140.
    Elssner A, Vogelmeier C. The role of neutrophils in the pathogenesis of obliterative bronchiolitis after lung transplantation. Transplant Infect Dis 2001;3:168–176.CrossRefGoogle Scholar
  141. 141.
    Lu F, Zander DS, Visner GA. Increased expression of heme oxygenase-1 in human lung transplantation. J Heart Lung Transplant 2002;21:1120–1126.PubMedCrossRefGoogle Scholar
  142. 142.
    Slebos DJ, Postma DS, Koeter GH, Van Der Bij W, Boezen M, Kauffman HE. Bronchoalveolar lavage fluid characteristics in acute and chronic lung transplant rejection. J Heart Lung Transplant 2004;23:532–540.PubMedCrossRefGoogle Scholar
  143. 143.
    Reid D, Snell G, Ward C, et al. Iron overload and nitric oxide-derived oxidative stress following lung transplantation. J Heart Lung Transplant 2001;20:840–849.PubMedCrossRefGoogle Scholar
  144. 144.
    Baz MA, Tapson VF, Roggli VL, Van Trigt P, Piantadosi CA. Glutathione depletion in epithelial lining fluid of lung allograft patients. Am J Respir Crit Care Med 1996;153:742–746.PubMedCrossRefGoogle Scholar
  145. 145.
    Sundaresan S, Alevy YG, Steward N, et al. Cytokine gene transcripts for tumor necrosis factor-alpha, interleukin-2, and interferon-gamma in human pulmonary allografts. J Heart Lung Transplant 1995;14:512–518.PubMedGoogle Scholar
  146. 146.
    Magnan A, Mege JL, Escallier JC, et al. Balance between alveolar macrophage IL-6 and TGF-beta in lung-transplant recipients. Marseille and Montreal Lung Transplantation Group. Am J Respir Crit Care Med 1996;153:1431–1436.PubMedCrossRefGoogle Scholar
  147. 147.
    Iacono A, Dauber J, Keenan R, et al. Interleukin 6 and interferon-gamma gene expression in lung transplant recipients with refractory acute cellular rejection: implications for monitoring and inhibition by treatment with aerosolized cyclosporine. Transplantation 1997;64:263–269.PubMedCrossRefGoogle Scholar
  148. 148.
    Rizzo M, SivaSai KS, Smith MA, et al. Increased expression of inflammatory cytokines and adhesion molecules by alveolar macrophages of human lung allograft recipients with acute rejection: decline with resolution of rejection. J Heart Lung Transplant 2000;19:858–865.PubMedCrossRefGoogle Scholar
  149. 149.
    Shreeniwas R, Schulman LL, Narasimhan M, McGregor CC, Marboe CC. Adhesion molecules (E-selectin and ICAM-1) in pulmonary allograft rejection. Chest 1996;110:1143–1149.PubMedCrossRefGoogle Scholar
  150. 150.
    Steinhoff G, Behrend M, Richter N, Schlitt HJ, Cremer J, Haverich A. Distinct expression of cell-cell and cell-matrix adhesion molecules on endothelial cells in human heart and lung transplants. J Heart Lung Transplant 1995;14:1145–1155.PubMedGoogle Scholar
  151. 151.
    Zander DS, Baz MA, Massey JK. Patterns and significance of CD44 expression in lung allografts. J Heart Lung Transplant 1999;18:646–653.PubMedCrossRefGoogle Scholar
  152. 152.
    Hertz MI, Henke CA, Nakhleh RE, et al. Obliterative bronchiolitis after lung transplantation: a fibroproliferative disorder associated with platelet-derived growth factor. Proc Natl Acad Sci 1992;89:10385–10389.PubMedCrossRefGoogle Scholar
  153. 153.
    Bergmann M, Tiroke A, Schafer H, Barth J, Haverich A. Gene expression of profibrotic mediators in bronchiolitis obliterans syndrome after lung transplantation. Scand Cardiovasc J 1998;32:97–103.PubMedCrossRefGoogle Scholar
  154. 154.
    El-Gamel A, Sim E, Hasleton P, et al. Transforming growth factor beta (TGF-beta) and obliterative bronchiolitis following pulmonary transplantation. J Heart Lung Transplant 1999;18:828–837.PubMedCrossRefGoogle Scholar
  155. 155.
    Charpin JM, Stern M, Grenet D, Israel-Biet D. Insulinlike growth factor-1 in lung transplants with obliterative bronchiolitis. Am J Respir Crit Care Med 2000;161:1991–1998.PubMedCrossRefGoogle Scholar
  156. 156.
    Yousem SA, Sonmez-Alpan E. Use of a biotinylated DNA probe specific for the human Y chromosome in the evaluation of the allograft lung. Chest 1991;99:275–279.PubMedCrossRefGoogle Scholar
  157. 157.
    Bittmann I, Dose T, Baretton GB, et al. Cellular chimerism of the lung after transplantation. An interphase cytogenetic study. Am J Clin Pathol 2001;115:525–533.PubMedCrossRefGoogle Scholar
  158. 158.
    Wiebe BM, Mortensen SA, Petterson G, Svendsen UG, Andersen CB. Macrophage and lymphocyte chimerism in bronchoalveolar lavage cells from human lung allograft recipients. Apmis 2001;109:435–440.PubMedCrossRefGoogle Scholar
  159. 159.
    Rothmeier C, Roux E, Spiliopoulos A, Gerbase M, Nicod LP. Early chimerism of macrophages and lymphocytes in lung transplant recipients is predictive of graft tolerance. Transplantation 2001;71:1329–1333.PubMedCrossRefGoogle Scholar
  160. 160.
    Kleeberger W, Versmold A, Rothamel T, et al. Increased chimerism of bronchial and alveolar epithelium in human lung allografts undergoing chronic injury. Am J Pathol 2003;162:1487–1494.PubMedCrossRefGoogle Scholar
  161. 161.
    Zander DS, Baz MA, Cogle CR, Visner GA, Theise ND, Crawford JM. Bone marrow-derived stem cell repopulation contributes minimally to the type II pneumocyte pool in transplanted human lungs. Transplantation 2005;80:206–212.PubMedCrossRefGoogle Scholar
  162. 162.
    Ionescu DN, Hunt JL, Lomago D, Yousem SA. Recurrent sarcoidosis in lung transplant allograft—are granulomas of recipient origin? Mod Pathol 2005;18:312A–313A.Google Scholar
  163. 163.
    Bittmann I, Rolf B, Amann G, Lohrs U. Recurrence of lymphangioleiomyomatosis after single lung transplantation: new insights into pathogenesis. Hum Pathol 2003;34:95–98.PubMedCrossRefGoogle Scholar
  164. 164.
    Karbowniczek M, Astrinidis A, Balsara BR, et al. Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism. Am J Respir Crit Care Med 2003;167:976–982.PubMedCrossRefGoogle Scholar
  165. 165.
    Garver RI, Jr, Zorn GL, Wu X, McGiffin DC, Young KR, Jr, Pinkard NB. Recurrence of bronchioloalveolar carcinoma in transplanted lungs. N Engl J Med 1999;340:1071–1074.PubMedCrossRefGoogle Scholar
  166. 166.
    Paloyan EB, Swinnen LJ, Montoya A, Lonchyna V, Sullivan HJ, Garrity E. Lung transplantation for advanced bronchioloalveolar carcinoma confined to the lungs. Transplantation 2000;69:2446–2448.PubMedCrossRefGoogle Scholar
  167. 167.
    Zorn GL Jr, McGiffin DC, Young KR Jr, Alexander CB, Weill D, Kirklin JK. Pulmonary transplantation for advanced bronchioloalveolar carcinoma. J Thorac Cardiovasc Surg 2003;125:45–48.PubMedCrossRefGoogle Scholar
  168. 168.
    Yousem SA. Alveolar lipoproteinosis in lung allograft recipients. Hum Pathol 1997;28:1383–1386.PubMedCrossRefGoogle Scholar
  169. 169.
    Gal AA, Bryan JA, Kanter KR, Lawrence EC. Cytopathology of pulmonary alveolar proteinosis complicating lung transplantation. J Heart Lung Transplant 2004;23:135–138.PubMedCrossRefGoogle Scholar
  170. 170.
    Burns KE, Iacono AT. Pulmonary embolism on postmortem examination: an under-recognized complication in lung-transplant recipients? Transplantation 2004;77:692–698.PubMedCrossRefGoogle Scholar
  171. 171.
    Zhao Y, Al-Kaade S, Keller CA, deMello DE. Atelectasis—an unusual and late complication of lung transplant. Clin Transplant 2002;16:233–239.PubMedCrossRefGoogle Scholar
  172. 172.
    Buell JF, Trofe J, Hanaway MJ, et al. Transmission of donor cancer into cardiothoracic transplant recipients. Surgery 2001;130:660–666.PubMedCrossRefGoogle Scholar
  173. 173.
    Armanios MY, Grossman SA, Yang SC, et al. Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: case study and review of the literature. Neuro-Oncol 2004;6:259–263.PubMedCrossRefGoogle Scholar
  174. 174.
    Rosendale BE, Keenan RJ, Duncan SR, et al. Donor cerebral emboli as a cause of acute graft dysfunction in lung transplantation. J Heart Lung Transplant 1992;11:72–76.PubMedGoogle Scholar
  175. 175.
    Yousem SA, Duncan SR, Griffith BP. Interstitial and airspace granulation tissue reactions in lung transplant recipients. Am J Surg Pathol 1992;16:877–884.PubMedCrossRefGoogle Scholar
  176. 176.
    Chaparro C, Chamberlain D, Maurer J, Winton T, Dehoyos A, Kesten S. Bronchiolitis obliterans organizing pneumonia (BOOP) in lung transplant recipients. Chest 1996;110:1150–1154.PubMedCrossRefGoogle Scholar
  177. 177.
    Siddiqui MT, Garrity ER, Husain AN. Bronchiolitis obliterans organizing pneumonia-like reactions: a nonspecific response or an atypical form of rejection or infection in lung allograft recipients? Hum Pathol 1996;27:714–719.PubMedCrossRefGoogle Scholar
  178. 178.
    Milne DS, Gascoigne AD, Ashcroft T, Sviland L, Malcolm AJ, Corris PA. Organizing pneumonia following pulmonary transplantation and the development of obliterative bronchiolitis. Transplantation 1994;57:1757–1762.PubMedGoogle Scholar
  179. 179.
    Clelland CA, Higenbottam TW, Stewart S, Scott JP, Wallwork J. The histological changes in transbronchial biopsy after treatment of acute lung rejection in heart-lung transplants. J Pathol 1990;161:105–112.PubMedCrossRefGoogle Scholar
  180. 180.
    Hasegawa T, Iacono A, Yousem SA. The significance of bronchus-associated lymphoid tissue in human lung transplantation: is there an association with acute and chronic rejection? Transplantation 1999;67:381–385.PubMedCrossRefGoogle Scholar
  181. 181.
    Reid KR, McKenzie FN, Menkis AH, et al. Importance of chronic aspiration in recipients of heart-lung transplants. Lancet 1990;336:206–208.PubMedCrossRefGoogle Scholar
  182. 182.
    Berkowitz N, Schulman LL, McGregor C, Markowitz D. Gastroparesis after lung transplantation. Potential role in postoperative respiratory complications. Chest 1995;108:1602–1607.PubMedCrossRefGoogle Scholar
  183. 183.
    Akindipe OA, Faul JL, Vierra MA, Triadafilopoulos G, Theodore J. The surgical management of severe gastroparesis in heart/lung transplant recipients. Chest 2000;117:907–910.PubMedCrossRefGoogle Scholar
  184. 184.
    Abernathy EC, Hruban RH, Baumgartner WA, Reitz BA, Hutchins GM. The two forms of bronchiolitis obliterans in heart-lung transplant recipients. Hum Pathol 1991;22:1102–1110.PubMedCrossRefGoogle Scholar
  185. 185.
    Frost AE, Keller CA, Cagle PT. Severe ischemic injury to the proximal airway following lung transplantation. Immediate and long-term effects on bronchial cartilage. Multi-Organ Transplant Group. Chest 1993;103:1899–1901.PubMedCrossRefGoogle Scholar
  186. 186.
    Goldfarb NS, Avery RK, Goormastic M, et al. Hypogammaglobulinemia in lung transplant recipients. Transplantation 2001;71:242–246.PubMedCrossRefGoogle Scholar
  187. 187.
    Kubak BM. Fungal infection in lung transplantation. Transplant Infect Dis 2002;4(suppl 3):24–31.CrossRefGoogle Scholar
  188. 188.
    Husain AN, Siddiqui MT, Reddy VB, Yeldandi V, Montoya A, Garrity ER. Postmortem findings in lung transplant recipients. Mod Pathol 1996;9:752–761.PubMedGoogle Scholar
  189. 189.
    Kesten S, Chaparro C. Mycobacterial infections in lung transplant recipients. Chest 1999;115:741–745.PubMedCrossRefGoogle Scholar
  190. 190.
    Schulman LL, Htun T, Staniloae C, McGregor CC, Austin JH. Pulmonary nodules and masses after lung and heart-lung transplantation. J Thorac Imaging 2000;15:173–179.PubMedCrossRefGoogle Scholar
  191. 191.
    Husain S, McCurry K, Dauber J, Singh N, Kusne S. Nocardia infection in lung transplant recipients. J Heart Lung Transplant 2002;21:354–359.PubMedCrossRefGoogle Scholar
  192. 192.
    Keenan RJ, Lega ME, Dummer JS, et al. Cytomegalovirus serologic status and postoperative infection correlated with risk of developing chronic rejection after pulmonary transplantation. Transplantation 1991;51:433–438.PubMedCrossRefGoogle Scholar
  193. 193.
    Keller CA, Cagle PT, Brown RW, Noon G, Frost AE. Bronchiolitis obliterans in recipients of single, double, and heart-lung transplantation. Chest 1995;107:973–980.PubMedCrossRefGoogle Scholar
  194. 194.
    Sharpies LD, Tamm M, McNeil K, Higenbottam TW, Stewart S, Wallwork J. Development of bronchiolitis obliterans syndrome in recipients of heart-lung transplantation—early risk factors. Transplantation 1996;61:560–566.CrossRefGoogle Scholar
  195. 195.
    Khalifah AP, Hachem RR, Chakinala MM, et al. Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death. Am J Respir Crit Care Med 2004;170:181–187.PubMedCrossRefGoogle Scholar
  196. 196.
    Maurer JR, Tullis DE, Grossman RF, Vellend H, Winton TL, Patterson GA. Infectious complications following isolated lung transplantation. Chest 1992;101:1056–1059.PubMedCrossRefGoogle Scholar
  197. 197.
    Kramer MR, Marshall SE, Starnes VA, Gamberg P, Amitai Z, Theodore J. Infectious complications in heart-lung transplantation. Analysis of 200 episodes. Arch Intern Med 1993;153:2010–2016.PubMedCrossRefGoogle Scholar
  198. 198.
    Paradis IL, Williams P. Infection after lung transplantation. Semin Respir Infect 1993;8:207–215.PubMedGoogle Scholar
  199. 199.
    Chan CC, Abi-Saleh WJ, Arroliga AC, et al. Diagnostic yield and therapeutic impact of flexible bronchoscopy in lung transplant recipients. J Heart Lung Transplant 1996;15:196–205.PubMedGoogle Scholar
  200. 200.
    Deusch E, End A, Grimm M, Graninger W, Klepetko W, Wolner E. Early bacterial infections in lung transplant recipients. Chest 1993;104:1412–146.PubMedCrossRefGoogle Scholar
  201. 201.
    Roberts SA, Franklin JC, Mijch A, Spelman D. Nocardia infection in heart-lung transplant recipients at Alfred Hospital, Melbourne, Australia, 1989–1998. Clin Infect Dis 2000;31:968–972.PubMedCrossRefGoogle Scholar
  202. 202.
    Lyon GM, Alspaugh JA, Meredith FT, et al. Mycoplasma hominis pneumonia complicating bilateral lung transplantation: case report and review of the literature. Chest 1997;112:1428–1432.PubMedCrossRefGoogle Scholar
  203. 203.
    Douglas RG, Jr, Anderson S, Weg JG, et al. Herpes simplex virus pneumonia. Occurrence in an allotransplanted lung. JAMA 1969;210:902–904.PubMedCrossRefGoogle Scholar
  204. 204.
    Fend F, Prior C, Margreiter R, Mikuz G. Cytomegalovirus pneumonitis in heart-lung transplant recipients: histopathology and clinicopathologic considerations. Hum Pathol 1990;21:918–926.PubMedCrossRefGoogle Scholar
  205. 205.
    Smyth RL, Higenbottam TW, Scott JP, et al. Herpes simplex virus infection in heart-lung transplant recipients. Transplantation 1990;49:735–739.PubMedCrossRefGoogle Scholar
  206. 206.
    Husain AN, Siddiqui MT, Montoya A, Chandrasekhar AJ, Garrity ER. Post-lung transplant biopsies: an 8-year Loyola experience. Mod Pathol 1996;9:126–132.PubMedGoogle Scholar
  207. 207.
    Smyth RL, Scott JP, Borysiewicz LK, et al. Cytomegalovirus infection in heart-lung transplant recipients: risk factors, clinical associations, and response to treatment. J Infect Dis 1991;164:1045–1050.PubMedCrossRefGoogle Scholar
  208. 208.
    Wendt CH, Fox JM, Hertz MI. Paramyxovirus infection in lung transplant recipients. J Heart Lung Transplant 1995;14:479–485.PubMedGoogle Scholar
  209. 209.
    Palmer SM, Jr, Henshaw NG, Howell DN, Miller SE, Davis RD, Tapson VF. Community respiratory viral infection in adult lung transplant recipients. Chest 1998;113:944–950.PubMedCrossRefGoogle Scholar
  210. 210.
    Billings JL, Hertz MI, Wendt CH. Community respiratory virus infections following lung transplantation. Transplant Infect Dis 2001;3:138–148.CrossRefGoogle Scholar
  211. 211.
    Vilchez R, McCurry K, Dauber J, et al. Influenza and parainfluenza respiratory viral infection requiring admission in adult lung transplant recipients. Transplantation 2002;73:1075–1078.PubMedCrossRefGoogle Scholar
  212. 212.
    Ohori NP, Michaels MG, Jaffe R, Williams P, Yousem SA. Adenovirus pneumonia in lung transplant recipients. Hum Pathol 1995;26:1073–1079.PubMedCrossRefGoogle Scholar
  213. 213.
    Simsir A, Greenebaum E, Nuovo G, Schulman LL. Late fatal adenovirus pneumonitis in a lung transplant recipient. Transplantation 1998;65:592–594.PubMedCrossRefGoogle Scholar
  214. 214.
    Vilchez RA, McCurry K, Dauber J, et al. Influenza virus infection in adult solid organ transplant recipients. Am J Transplant 2002;2:287–291.PubMedCrossRefGoogle Scholar
  215. 215.
    Garantziotis S, Howell DN, McAdams HP, Davis RD, Henshaw NG, Palmer SM. Influenza pneumonia in lung transplant recipients: clinical features and association with bronchiolitis obliterans syndrome. Chest 2001;119:1277–1280.PubMedCrossRefGoogle Scholar
  216. 216.
    Vilchez RA, McCurry K, Dauber J, et al. The epidemiology of parainfluenza virus infection in lung transplant recipients. Clin Infect Dis 2001;33:2004–2008.PubMedCrossRefGoogle Scholar
  217. 217.
    Marchevsky A, Hartman G, Walts A, Ross D, Koerner S, Waters P. Lung transplantation: the pathologic diagnosis of pulmonary complications. Mod Pathol 1991;4:133–138.PubMedGoogle Scholar
  218. 218.
    Patel SR, Kirby TJ, McCarthy PM, et al. Lung transplantation: the Cleveland Clinic experience. Cleve Clin J Med 1993;60:303–319.PubMedGoogle Scholar
  219. 219.
    Nunley DR, Gal AA, Vega JD, Perlino C, Smith P, Lawrence EC. Saprophytic fungal infections and complications involving the bronchial anastomosis following human lung transplantation. Chest 2002;122:1185–1191.PubMedCrossRefGoogle Scholar
  220. 220.
    Helmi M, Love RB, Welter D, Cornwell RD, Meyer KC. Aspergillus infection in lung transplant recipients with cystic fibrosis: risk factors and outcomes comparison to other types of transplant recipients. Chest 2003;123:800–808.PubMedCrossRefGoogle Scholar
  221. 221.
    Judson MA. Clinical aspects of lung transplantation. Clin Chest Med 1993;14:335–357.PubMedGoogle Scholar
  222. 222.
    Davis RD Jr, Pasque MK. Pulmonary transplantation. Ann Surg 1995;221:14–28.PubMedCrossRefGoogle Scholar
  223. 223.
    Grossi P, Farina C, Fiocchi R, Dalla Gasperina D. Prevalence and outcome of invasive fungal infections in 1,963 thoracic organ transplant recipients: a multicenter retrospective study. Italian Study Group of Fungal Infections in Thoracic Organ Transplant Recipients. Transplantation 2000;70:112–116.PubMedGoogle Scholar
  224. 224.
    Tamm M, Malouf M, Glanville A. Pulmonary Scedospo-rium infection following lung transplantation. Transplant Infect Dis 2001;3:189–194.CrossRefGoogle Scholar
  225. 225.
    Mehrad B, Paciocco G, Martinez FJ, Ojo TC, Iannettoni MD, Lynch JP 3rd. Spectrum of Aspergillus infection in lung transplant recipients: case series and review of the literature. Chest 2001;119:169–175.PubMedCrossRefGoogle Scholar
  226. 226.
    Tazelaar HD, Baird AM, Mill M, Grimes MM, Schulman LL, Smith CR. Bronchocentric mycosis occurring in transplant recipients. Chest 1989;96:92–95.PubMedCrossRefGoogle Scholar
  227. 227.
    Castiglioni B, Sutton DA, Rinaldi MG, Fung J, Kusne S. Pseudallescheria boydii (Anamorph Scedosporium apiospermum). Infection in solid organ transplant recipients in a tertiary medical center and review of the literature. Medicine (Baltimore) 2002;81:333–348.PubMedCrossRefGoogle Scholar
  228. 228.
    Hunstad DA, Cohen AH, St. Geme JW 3rd. Successful eradication of mucormycosis occurring in a pulmonary allograft. J Heart Lung Transplant 1999;18:801–804.PubMedCrossRefGoogle Scholar
  229. 229.
    Zander DS, Cicale MJ, Mergo P. Durable cure of mucormycosis involving allograft and native lungs. J Heart Lung Transplant 2000;19:615–618.PubMedCrossRefGoogle Scholar
  230. 230.
    Mattner F, Weissbrodt H, Strueber M. Two case reports: fatal Absidia corymbifera pulmonary tract infection in the first postoperative phase of a lung transplant patient receiving voriconazole prophylaxis, and transient bronchial Absidia corymbifera colonization in a lung transplant patient. Scand J Infect Dis 2004;36:312–314.PubMedCrossRefGoogle Scholar
  231. 231.
    Chaparro C, Kesten S. Infections in lung transplant recipients. Clin Chest Med 1997;18:339–351.PubMedCrossRefGoogle Scholar
  232. 232.
    Fishman JA. Prevention of infection caused by Pneumocystis carinii in transplant recipients. Clin Infect Dis 2001;33:1397–1405.PubMedCrossRefGoogle Scholar
  233. 233.
    Malouf MA, Glanville AR. The spectrum of mycobacterial infection after lung transplantation. Am J Respir Crit Care Med 1999;160:1611–1616.PubMedCrossRefGoogle Scholar
  234. 234.
    Trulock EP, Bolman RM, Genton R. Pulmonary disease caused by Mycobacterium chelonae in a heart-lung transplant recipient with obliterative bronchiolitis. Am Rev Respir Dis 1989;140:802–805.PubMedCrossRefGoogle Scholar
  235. 235.
    Paciocco G, Martinez FJ, Kazerooni EA, Bossone E, Lynch JP 3rd. Tuberculous pneumonia complicating lung transplantation: case report and review of the literature. Monaldi Arch Chest Dis 2000;55:117–121.PubMedGoogle Scholar
  236. 236.
    Sanguinetti M, Ardito F, Fiscarelli E, et al. Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis. J Clin Microbiol 2001;39:816–819.PubMedCrossRefGoogle Scholar
  237. 237.
    Baldi S, Rapellino M, Ruffini E, Cavallo A, Mancuso M. Atypical mycobacteriosis in a lung transplant recipient. Eur Respir J 1997;10:952–954.PubMedGoogle Scholar
  238. 238.
    Fairhurst RM, Kubak BM, Shpiner RB, Levine MS, Pegues DA, Ardehali A. Mycobacterium abscessus empyema in a lung transplant recipient. J Heart Lung Transplant 2002;21:391–394.PubMedCrossRefGoogle Scholar
  239. 239.
    Wreghitt TG, Gray JJ, Pavel P, et al. Efficacy of pyrimethamine for the prevention of donor-acquired Toxoplasma gondii infection in heart and heart-lung transplant patients. Transplant Int 1992;5:197–200.CrossRefGoogle Scholar
  240. 240.
    Patel R, Paya CV. Infections in solid-organ transplant recipients. Clin Microbiol Rev 1997;10:86–124.PubMedGoogle Scholar
  241. 241.
    Fishman JA, Rubin RH. Infection in organ-transplant recipients. N Engl J Med 1998;338:1741–1751.PubMedCrossRefGoogle Scholar
  242. 242.
    Dunn DL. Hazardous crossing: immunosuppression and nosocomial infections in solid organ transplant recipients. Surg Infect (Larchmt) 2001;2:103–110.CrossRefGoogle Scholar
  243. 243.
    Colby TV, Hunt S, Pelzmann K, Carrington CB. Malako-plakia of the lung: a report of two cases. Respiration 1980;39:295–299.PubMedCrossRefGoogle Scholar
  244. 244.
    Munoz P, Burillo A, Palomo J, Rodriguez-Creixems M, Bouza E. Rhodococcus equi infection in transplant recipients: case report and review of the literature. Transplantation 1998;65:449–453.PubMedCrossRefGoogle Scholar
  245. 245.
    Perez MG, Vassilev T, Kemmerly SA. Rhodococcus equi infection in transplant recipients: a case of mistaken identity and review of the literature. Transplant Infect Dis 2002;4:52–56.CrossRefGoogle Scholar
  246. 246.
    McGrath D, Falagas ME, Freeman R, et al. Adenovirus infection in adult orthotopic liver transplant recipients: incidence and clinical significance. J Infect Dis 1998;177:459–462.PubMedCrossRefGoogle Scholar
  247. 247.
    Vilchez RA, Fung J, Kusne S. The pathogenesis and management of influenza virus infection in organ transplant recipients. Transplant Infect Dis 2002;4:177–182.CrossRefGoogle Scholar
  248. 248.
    Patterson JE. Epidemiology of fungal infections in solid organ transplant patients. Transplant Infect Dis 1999;1:229–236.CrossRefGoogle Scholar
  249. 249.
    Bag R. Fungal pneumonias in transplant recipients. Curr Opin Pulm Med 2003;9:193–198.PubMedCrossRefGoogle Scholar
  250. 250.
    Hagerty JA, Ortiz J, Reich D, Manzarbeitia C. Fungal infections in solid organ transplant patients. Surg Infect (Larchmt) 2003;4:263–271.CrossRefGoogle Scholar
  251. 251.
    Husain S, Wagener MM, Singh N. Cryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcome. Emerg Infect Dis 2001;7:375–381.PubMedGoogle Scholar
  252. 252.
    Vilchez RA, Irish W, Lacomis J, Costello P, Fung J, Kusne S. The clinical epidemiology of pulmonary cryptococcosis in non-AIDS patients at a tertiary care medical center. Medicine (Baltimore) 2001;80:308–312.PubMedCrossRefGoogle Scholar
  253. 253.
    Vilchez RA, Fung J, Kusne S. Cryptococcosis in organ transplant recipients: an overview. Am J Transplant 2002;2:575–580.PubMedCrossRefGoogle Scholar
  254. 254.
    Mueller NJ, Fishman JA. Asymptomatic pulmonary cryptococcosis in solid organ transplantation: report of four cases and review of the literature. Transplant Infect Dis 2003;5:140–143.CrossRefGoogle Scholar
  255. 255.
    Singh N, Gayowski T, Singh J, Yu VL. Invasive gastrointestinal zygomycosis in a liver transplant recipient: case report and review of zygomycosis in solid-organ transplant recipients. Clin Infect Dis 1995;20:617–620.PubMedCrossRefGoogle Scholar
  256. 256.
    Latif S, Saffarian N, Bellovich K, Provenzano R. Pulmonary mucormycosis in diabetic renal allograft recipients. Am J Kidney Dis 1997;29:461–464.PubMedCrossRefGoogle Scholar
  257. 257.
    Demirag A, Elkhammas EA, Henry ML, et al. Pulmonary Rhizopus infection in a diabetic renal transplant recipient. Clin Transplant 2000;14:8–10.PubMedCrossRefGoogle Scholar
  258. 258.
    Malani PN, Bleicher JJ, Kauffman CA, Davenport DS. Disseminated Dactylaria constricta infection in a renal transplant recipient. Transplant Infect Dis 2001;3:40–43.CrossRefGoogle Scholar
  259. 259.
    Wang TK, Chiu W, Chim S, Chan TM, Wong SS, Ho PL. Disseminated ochroconis gallopavum infection in a renal transplant recipient: the first reported case and a review of the literature. Clin Nephrol 2003;60:415–423.PubMedGoogle Scholar
  260. 260.
    Munoz P, Munoz RM, Palomo J, Rodriguez-Creixems M, Munoz R, Bouza E. Pneumocystis carinii infection in heart transplant recipients. Efficacy of a weekend prophylaxis schedule. Medicine (Baltimore) 1997;76:415–422.PubMedCrossRefGoogle Scholar
  261. 261.
    Munoz P, Palomo J, Munoz R, Rodriguez-Creixems M, Pelaez T, Bouza E. Tuberculosis in heart transplant recipients. Clin Infect Dis 1995;21:398–402.PubMedCrossRefGoogle Scholar
  262. 262.
    Doucette K, Fishman JA. Nontuberculous mycobacterial infection in hematopoietic stem cell and solid organ transplant recipients. Clin Infect Dis 2004;38:1428–1439.PubMedCrossRefGoogle Scholar
  263. 263.
    Ersoy A, Gullulu M, Usta M, et al. A renal transplant recipient with pulmonary tuberculosis and visceral leishmaniasis: review of superimposed infections and therapy approaches. Clin Nephrol 2003;60:289–294.PubMedGoogle Scholar
  264. 264.
    Bombi JA, Cardesa A, Llebaria C, et al. Main autopsy findings in bone marrow transplant patients. Arch Pathol Lab Med 1987;111:125–129.PubMedGoogle Scholar
  265. 265.
    Somboonwit C, Greene JN. Diagnostic methodologies for invasive fungal infections in hematopoietic stem-cell transplant recipients. Semin Respir Infect 2002;17:151–157.PubMedCrossRefGoogle Scholar
  266. 266.
    Veys P, Owens C. Respiratory infections following haemopoietic stem cell transplantation in children. Br Med Bull 2002;61:151–174.PubMedCrossRefGoogle Scholar
  267. 267.
    Kugler JW, Armitage JO, Helms CM, et al. Nosocomial Legionnaires’ disease. Occurrence in recipients of bone marrow transplants. Am J Med 1983;74:281–288.PubMedCrossRefGoogle Scholar
  268. 268.
    Barbera JA, Martin-Campos JM, Ribalta T, et al. Undetected viral infection in diffuse alveolar damage associated with bone marrow transplantation. Eur Respir J 1996;9:1195–1200.PubMedCrossRefGoogle Scholar
  269. 269.
    Castagnola E, Cappelli B, Erba D, Rabagliati A, Lanino E, Dini G. Cytomegalovirus infection after bone marrow transplantation in children. Hum Immunol 2004;65:416–422.PubMedCrossRefGoogle Scholar
  270. 270.
    Li CR, Greenberg PD, Gilbert MJ, Goodrich JM, Riddell SR. Recovery of HLA-restricted cytomegalovirus (CMV)-specific T cell responses after allogeneic bone marrow transplant: correlation with CMV disease and effect of ganciclovir prophylaxis. Blood 1994;83:1971–1979.PubMedGoogle Scholar
  271. 271.
    Zaia JA, Forman SJ. Cytomegalovirus infection in the bone marrow transplant recipient. Infect Dis Clin North Am 1995;9:879–900.PubMedGoogle Scholar
  272. 272.
    Locksley RM, Flournoy N, Sullivan KM, Meyers JD. Infection with varicella-zoster virus after marrow transplantation. J Infect Dis 1985;152:1172–1181.PubMedCrossRefGoogle Scholar
  273. 273.
    Grant RM, Weitzman SS, Sherman CG, Sirkin WL, Petric M, Tellier R. Fulminant disseminated Varicella Zoster virus infection without skin involvement. J Clin Virol 2002;24:7–12.PubMedCrossRefGoogle Scholar
  274. 274.
    Cone RW, Hackman RC, Huang ML, et al. Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation. N Engl J Med 1993;329:156–161.PubMedCrossRefGoogle Scholar
  275. 275.
    Hertz MI, Englund JA, Snover D, Bitterman PB, McGlave PB. Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature. Medicine (Baltimore) 1989;68:269–281.PubMedCrossRefGoogle Scholar
  276. 276.
    Whimbey E, Englund JA, Couch RB. Community respiratory virus infections in immunocompromised patients with cancer. Am J Med 1997;102:10–18.PubMedCrossRefGoogle Scholar
  277. 277.
    Lewis VA, Champlin R, Englund J, et al. Respiratory disease due to parainfluenza virus in adult bone marrow transplant recipients. Clin Infect Dis 1996;23:1033–1037.PubMedCrossRefGoogle Scholar
  278. 278.
    Wendt CH, Weisdorf DJ, Jordan MC, Balfour HHJ, Hertz MI. Parainfluenza virus respiratory infection after bone marrow transplantation. N Engl J Med 1992;326:921–926.PubMedCrossRefGoogle Scholar
  279. 279.
    Hale GA, Heslop HE, Krance RA, et al. Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transplant 1999;23:277–282.PubMedCrossRefGoogle Scholar
  280. 280.
    Markovic SN, Adlakha A, Smith TF, Walker RC. Respiratory syncytial virus pneumonitis-induced diffuse alveolar damage in an autologous bone marrow transplant recipient. Mayo Clin Proc 1998;73:153–156.PubMedCrossRefGoogle Scholar
  281. 281.
    Kurzrock R, Zander A, Vellekoop L, Kanojia M, Luna M, Dicke K. Mycobacterial pulmonary infections after allogeneic bone marrow transplantation. Am J Med 1984;77:35–40.PubMedCrossRefGoogle Scholar
  282. 282.
    Ip MS, Yuen KY, Woo PC, et al. Risk factors for pulmonary tuberculosis in bone marrow transplant recipients. Am J Respir Crit Care Med 1998;158:1173–1177.PubMedCrossRefGoogle Scholar
  283. 283.
    Aljurf M, Gyger M, Alrajhi A, et al. Mycobacterium tuberculosis infection in allogeneic bone marrow transplantation patients. Bone Marrow Transplant 1999;24:551–554.PubMedCrossRefGoogle Scholar
  284. 284.
    Khan B, Ahmed P, Ullah K, Hussain CA, Hussain I, Raza S. Frequency of tuberculosis in haematological malignancies and stem cell transplant recipients. J Coll Physicians Surg Pak 2005;15:30–33.PubMedGoogle Scholar
  285. 285.
    Derouin F, Devergie A, Auber P, et al. Toxoplasmosis in bone marrow-transplant recipients: report of seven cases and review. Clin Infect Dis 1992;15:267–270.PubMedCrossRefGoogle Scholar
  286. 286.
    Saad R, Vincent JF, Cimon B, et al. Pulmonary toxoplasmosis after allogeneic bone marrow transplantation: case report and review. Bone Marrow Transplant 1996;18:211–212.PubMedGoogle Scholar
  287. 287.
    Paranjothi S, Yusen RD, Kraus MD, Lynch JP, Patterson GA, Trulock EP. Lymphoproliferative disease after lung transplantation: comparison of presentation and outcome of early and late cases. J Heart Lung Transplant 2001;20:1054–1063.PubMedCrossRefGoogle Scholar
  288. 288.
    Ramalingam P, Rybicki L, Smith MD, et al. Posttransplant lymphoproliferative disorders in lung transplant patients: the Cleveland Clinic experience. Mod Pathol 2002;15:647–656.PubMedCrossRefGoogle Scholar
  289. 289.
    Reams BD, McAdams HP, Howell DN, Steele MP, Davis RD, Palmer SM. Posttransplant lymphoproliferative disorder: incidence, presentation, and response to treatment in lung transplant recipients. Chest 2003;124:1242–1249.PubMedCrossRefGoogle Scholar
  290. 290.
    Yousem SA, Randhawa P, Locker J, et al. Posttransplant lymphoproliferative disorders in heart-lung transplant recipients: primary presentation in the allograft. Hum Pathol 1989;20:361–369.PubMedCrossRefGoogle Scholar
  291. 291.
    Egan JJ, Hasleton PS, Yonan N, et al. Necrotic, ulcerative bronchitis, the presenting feature of lymphoproliferative disease following heart-lung transplantation. Thorax 1995;50:205–207.PubMedCrossRefGoogle Scholar
  292. 292.
    Ho M, Jaffe R, Miller G, et al. The frequency of Epstein-Barr virus infection and associated lymphoproliferative syndrome after transplantation and its manifestations in children. Transplantation 1988;45:719–727.PubMedCrossRefGoogle Scholar
  293. 293.
    Randhawa PS, Jaffe R, Demetris AJ, et al. Expression of Epstein-Barr virus-encoded small RNA (by the EBER-1 gene) in liver specimens from transplant recipients with post-transplantation lymphoproliferative disease. N Engl J Med 1992;327:1710–1714.PubMedCrossRefGoogle Scholar
  294. 294.
    Chadburn A, Suciu-Foca N, Cesarman E, Reed E, Michler RE, Knowles DM. Post-transplantation lymphoproliferative disorders arising in solid organ transplant recipients are usually of recipient origin. Am J Pathol 1995;147:1862–1870.PubMedGoogle Scholar
  295. 295.
    Larson RS, Scott MA, McCurley TL, Vnencak-Jones CL. Microsatellite analysis of posttransplant lymphoproliferative disorders: determination of donor/recipient origin and identification of putative lymphomagenic mechanism. Cancer Res 1996;56:4378–4381.PubMedGoogle Scholar
  296. 296.
    Le Frere-Belda MA, Martin N, Gaulard P, Zafrani ES. Donor or recipient origin of post-transplantation lymphoproliferative disorders: evaluation by in situ hybridization. Mod Pathol 1997;10:701–707.PubMedGoogle Scholar
  297. 297.
    Ng IO, Shek TW, Thung SN, et al. Microsatellite analysis in post-transplantation lymphoproliferative disorder to determine donor/recipient origin. Mod Pathol 2000;13:1180–1185.PubMedCrossRefGoogle Scholar
  298. 298.
    Petit B, Le Meur Y, Jaccard A, et al. Influence of host-recipient origin on clinical aspects of posttransplantation lymphoproliferative disorders in kidney transplantation. Transplantation 2002;73:265–271.PubMedCrossRefGoogle Scholar
  299. 299.
    Gulley ML, Swinnen LJ, Plaisance KT Jr, Schnell C, Grogan TM, Schneider BG. Tumor origin and CD20 expression in posttransplant lymphoproliferative disorder occurring in solid organ transplant recipients: implications for immune-based therapy. Transplantation 2003;76:959–964.PubMedCrossRefGoogle Scholar
  300. 300.
    Frizzera G, Hanto DW, Gajl-Peczalska KJ, et al. Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res 1981;41:4262–4279.PubMedGoogle Scholar
  301. 301.
    Nalesnik MA, Jaffe R, Starzl TE, et al. The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol 1988;133:173–192.PubMedGoogle Scholar
  302. 302.
    Knowles DM, Cesarman E, Chadburn A, et al. Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders. Blood 1995;85:552–565.PubMedGoogle Scholar
  303. 303.
    Harris NL, Ferry JA, Swerdlow SH. Posttransplant lymphoproliferative disorders: Summary of Society for Hematopathology Workshop. Semin Diagn Pathol 1997;14:8–14.PubMedGoogle Scholar
  304. 304.
    Beschorner WE, Saral R, Hutchins GM, Tutschka PJ, Santos GW. Lymphocytic bronchitis associated with graft-versus-host disease in recipients of bone-marrow transplants. N Engl J Med 1978;299:1030–1036.PubMedCrossRefGoogle Scholar
  305. 305.
    Johnson FL, Stokes DC, Ruggiero M, Dalla-Pozza L, Callihan TR. Chronic obstructive airways disease after bone marrow transplantation. J Pediatr 1984;105:370–376.PubMedCrossRefGoogle Scholar
  306. 306.
    Ralph DD, Springmeyer SC, Sullivan KM, Hackman RC, Storb R, Thomas ED. Rapidly progressive air-flow obstruction in marrow transplant recipients. Possible association between obliterative bronchiolitis and chronic graft-versus-host disease. Am Rev Respir Dis 1984;129:641–644.PubMedGoogle Scholar
  307. 307.
    Ostrow D, Buskard N, Hill RS, Vickars L, Churg A. Bronchiolitis obliterans complicating bone marrow transplantation. Chest 1985;87:828–830.PubMedCrossRefGoogle Scholar
  308. 308.
    Perreault C, Cousineau S, D’Angelo G, et al. Lymphoid interstitial pneumonia after allogeneic bone marrow transplantation. A possible manifestation of chronic graft-versus-host disease. Cancer 1985;55:1–9.PubMedCrossRefGoogle Scholar
  309. 309.
    Chan CK, Hyland RH, Hutcheon MA, et al. Small-airways disease in recipients of allogeneic bone marrow transplants. An analysis of 11 cases and a review of the literature. Medicine (Baltimore) 1987;66:327–340.PubMedCrossRefGoogle Scholar
  310. 310.
    Atkinson K, Turner J, Biggs JC, Dodds A, Concannon A. An acute pulmonary syndrome possibly representing acute graft-versus-host disease involving the lung interstitium. Bone Marrow Transplant 1991;8:231–234.PubMedGoogle Scholar
  311. 311.
    Schwarer AP, Hughes JM, Trotman-Dickenson B, Krausz T, Goldman JM. A chronic pulmonary syndrome associated with graft-versus-host disease after allogeneic marrow transplantation. Transplantation 1992;54:1002–1008.PubMedCrossRefGoogle Scholar
  312. 312.
    Workman DL, Clancy J Jr. Interstitial pneumonitis and lymphocytic bronchiolitis/bronchitis as a direct result of acute lethal graft-versus-host disease duplicate the histo-pathology of lung allograft rejection. Transplantation 1994;58:207–213.PubMedGoogle Scholar
  313. 313.
    Ferrara JL, Cooke KR, Pan L, Krenger W. The immunopathophysiology of acute graft-versus-host-disease. Stem Cells 1996;14:473–489.PubMedCrossRefGoogle Scholar
  314. 314.
    Cooke KR, Krenger W, Hill G, et al. Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. Blood 1998;92:2571–2580.PubMedGoogle Scholar
  315. 315.
    Knox KS, Behnia M, Smith LR, et al. Acute graft-versus-host disease of the lung after liver transplantation. Liver Transplant 2002;8:968–971.CrossRefGoogle Scholar
  316. 316.
    Urbanski SJ, Kossakowska AE, Curtis J, et al. Idiopathic small airways pathology in patients with graft-versus-host disease following allogeneic bone marrow transplantation. Am J Surg Pathol 1987;11:965–971.PubMedCrossRefGoogle Scholar
  317. 317.
    Yousem SA. The histological spectrum of pulmonary graft-versus-host disease in bone marrow transplant recipients. Hum Pathol 1995;26:668–675.PubMedCrossRefGoogle Scholar
  318. 318.
    Pham PT, Pham PC, Danovitch GM, et al. Sirolimus-associated pulmonary toxicity. Transplantation 2004;77:1215–1220.PubMedCrossRefGoogle Scholar
  319. 319.
    Morelon E, Stern M, Israel-Biet D, et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients. Transplantation 2001;72:787–790.PubMedCrossRefGoogle Scholar
  320. 320.
    McWilliams TJ, Levvey BJ, Russell PA, Milne DG, Snell GI. Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantation. J Heart Lung Transplant 2003;22:210–213.PubMedCrossRefGoogle Scholar
  321. 321.
    Vlahakis NE, Rickman OB, Morgenthaler T. Sirolimus-associated diffuse alveolar hemorrhage. Mayo Clin Proc 2004;79:541–545.PubMedCrossRefGoogle Scholar
  322. 322.
    Johnson BA, Duncan SR, Ohori NP, et al. Recurrence of sarcoidosis in pulmonary allograft recipients. Am Rev Respir Dis 1993;148:1373–1377.PubMedCrossRefGoogle Scholar
  323. 323.
    Bjortuft O, Foerster A, Boe J, Geiran O. Single lung transplantation as treatment for end-stage pulmonary sarcoidosis: recurrence of sarcoidosis in two different lung allografts in one patient. J Heart Lung Transplant 1994;13:24–29.PubMedGoogle Scholar
  324. 324.
    Kazerooni EA, Jackson C, Cascade PN. Sarcoidosis: recurrence of primary disease in transplanted lungs. Radiology 1994;192:461–464.PubMedGoogle Scholar
  325. 325.
    Martinez FJ, Orens JB, Deeb M, Brunsting LA, Flint A, Lynch JP. Recurrence of sarcoidosis following bilateral allogeneic lung transplantation. Chest 1994;106:1597–1599.PubMedCrossRefGoogle Scholar
  326. 326.
    Carre P, Rouquette I, Durand D, et al. Recurrence of sarcoidosis in a human lung allograft. Transplant Proc 1995;27:1686.PubMedGoogle Scholar
  327. 327.
    Martel S, Carre PC, Carrera G, Pipy B, Leophonte PJ. Tumour necrosis factor-alpha gene expression by alveolar macrophages in human lung allograft recipient with recurrence of sarcoidosis. Toulouse Lung Transplantation Group. Eur Respir J 1996;9:1087–1089.PubMedCrossRefGoogle Scholar
  328. 328.
    Yeatman M, McNeil K, Smith JA, et al. Lung transplantation in patients with systemic diseases: an eleven-year experience at Papworth Hospital. J Heart Lung Transplant 1996;15:144–149.PubMedGoogle Scholar
  329. 329.
    Pigula FA, Griffith BP, Zenati MA, Dauber JH, Yousem SA, Keenan RJ. Lung transplantation for respiratory failure resulting from systemic disease. Ann Thorac Surg 1997;64:1630–1634.PubMedCrossRefGoogle Scholar
  330. 330.
    Klemen H, Husain AN, Cagle PT, Garrity ER, Popper HH. Mycobacterial DNA in recurrent sarcoidosis in the transplanted lung—a PCR-based study on four cases. Virchows Arch 2000;436:365–369.PubMedCrossRefGoogle Scholar
  331. 331.
    Collins J, Hartman MJ, Warner TF, et al. Frequency and CT findings of recurrent disease after lung transplantation. Radiology 2001;219:503–509.PubMedGoogle Scholar
  332. 332.
    Nine JS, Yousem SA, Paradis IL, Keenan R, Griffith BP. Lymphangioleiomyomatosis: recurrence after lung transplantation. J Heart Lung Transplant 1994;13:714–719.PubMedGoogle Scholar
  333. 333.
    O’Brien JD, Lium JH, Parosa JF, Deyoung BR, Wick MR, Trulock EP. Lymphangiomyomatosis recurrence in the allograft after single-lung transplantation. Am J Respir Crit Care Med 1995;151:2033–2036.PubMedCrossRefGoogle Scholar
  334. 334.
    Boehler A, Speich R, Russi EW, Weder W. Lung transplantation for lymphangioleiomyomatosis. N Engl J Med 1996;335:1275–1280.PubMedCrossRefGoogle Scholar
  335. 335.
    Bittmann I, Dose TB, Muller C, Dienemann H, Vogelmeier C, Lohrs U. Lymphangioleiomyomatosis: recurrence after single lung transplantation. Hum Pathol 1997;28:1420–1423.PubMedCrossRefGoogle Scholar
  336. 336.
    Collins J, Muller NL, Kazerooni EA, McAdams HP, Leung AN, Love RB. Lung transplantation for lymphangioleiomyomatosis: role of imaging in the assessment of complications related to the underlying disease. Radiology 1999;210:325–332.PubMedGoogle Scholar
  337. 337.
    Pechet TT, Meyers BF, Guthrie TJ, et al. Lung transplantation for lymphangioleiomyomatosis. J Heart Lung Transplant 2004;23:301–308.PubMedCrossRefGoogle Scholar
  338. 338.
    King MB, Jessurun J, Hertz MI. Recurrence of desquamative interstitial pneumonia after lung transplantation. Am J Respir Crit Care Med 1997;156:2003–2005.PubMedCrossRefGoogle Scholar
  339. 339.
    Verleden GM, Sels F, Van Raemdonck D, Verbeken EK, Lerut T, Demedts M. Possible recurrence of desquamative interstitial pneumonitis in a single lung transplant recipient. Eur Respir J 1998;11:971–974.PubMedCrossRefGoogle Scholar
  340. 340.
    Frost AE, Keller CA, Brown RW, et al. Giant cell interstitial pneumonitis. Disease recurrence in the transplanted lung. Am Rev Respir Dis 1993;148:1401–1404.PubMedCrossRefGoogle Scholar
  341. 341.
    Habib SB, Congleton J, Carr D, et al. Recurrence of recipient Langerhans’ cell histiocytosis following bilateral lung transplantation. Thorax 1998;53:323–325.PubMedCrossRefGoogle Scholar
  342. 342.
    Gabbay E, Dark JH, Ashcroft T, et al. Recurrence of Langerhans’ cell granulomatosis following lung transplantation. Thorax 1998;53:326–327.PubMedCrossRefGoogle Scholar
  343. 343.
    Parker LA, Novotny DB. Recurrent alveolar proteinosis following double lung transplantation. Chest 1997;111:1457–1458.PubMedCrossRefGoogle Scholar
  344. 344.
    Santamaria F, Brancaccio G, Parenti G, et al. Recurrent fatal pulmonary alveolar proteinosis after heart-lung transplantation in a child with lysinuric protein intolerance. J Pediatr 2004;145:268–272.PubMedCrossRefGoogle Scholar
  345. 345.
    Baz MA, Kussin PS, Van Trigt P, Davis RD, Roggli VL, Tapson VF. Recurrence of diffuse panbronchiolitis after lung transplantation. Am J Respir Crit Care Med 1995;151:895–898.PubMedCrossRefGoogle Scholar
  346. 346.
    Fitzsimons EJ, Aris R, Patterson R. Recurrence of allergic bronchopulmonary aspergillosis in the posttransplant lungs of a cystic fibrosis patient. Chest 1997;112:281–282.PubMedCrossRefGoogle Scholar
  347. 347.
    Mal H, Guignabert C, Thabut G, et al. Recurrence of pulmonary emphysema in an alpha-1 proteinase inhibitor-deficient lung transplant recipient. Am J Respir Crit Care Med 2004;170:811–814.PubMedCrossRefGoogle Scholar
  348. 348.
    Calabrese F, Giacometti C, Rea F, et al. Recurrence of idiopathic pulmonary hemosiderosis in a young adult patient after bilateral single-lung transplantation. Transplantation 2002;74:1643–1645.PubMedCrossRefGoogle Scholar
  349. 349.
    Cook RC, Fradet G, English JC, et al. Recurrence of intravenous talc granulomatosis following single lung transplantation. Can Respir J 1998;5:511–514.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Dani S. Zander
    • 1
  1. 1.Department of PathologyPenn State Milton S. Hershey Medical CenterHersheyUSA

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