Tissue Procurement, Sampling, and Preparation

  • Joseph F. TomashefskiJr.


The approach to the morphological diagnosis of lung disease varies with the type of tissue sample submitted and the associated clinical setting. Tissue samples can be roughly grouped into three major categories: (1) small biopsy specimens; (2) surgical lung biopsy specimens; and (3) large specimens including those obtained by lobectomy, pneumonectomy, or autopsy. The clinical situation usually dictates the manner of tissue procurement. For example, a central endobronchial lesion is approached via endoscopic biopsy under direct visualization, whereas a peripheral or perihilar mass is better accessed by a computed tomography (CT)-guided transthoracic or an endoscopic transbronchial needle biopsy, respectively. Transbronchial forceps lung biopsy is often the initial procedure in stable immunocompetent patients with interstitial lung disease, but an open lung biopsy or a biopsy obtained by video-assisted thoracoscopc surgery (VATS) may be the preferred diagnostic modality in immunosuppressed patients with rapidly evolving pulmonary infiltrates. Regardless of the means of tissue procurement, a review of the clinical and radiological data by the pathologist is essential for appropriate tissue handling and interpretation.


Acquire Immune Deficiency Syndrome Lung Biopsy Transbronchial Biopsy Open Lung Biopsy Tissue Procurement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Joseph F. TomashefskiJr.
    • 1
    • 2
  1. 1.Department of PathologyCase Western Reserve University School of MedicineClevelandUSA
  2. 2.Department of PathologyMetroHealth Medical CenterClevelandUSA

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