The administration of antibiotics to animals to prevent or treat diseases led us to be concerned about the impact of these antibiotics on human health. In fact, animal products could be a potential vehicle to transfer drugs to humans. Using appropri ated mathematical and statistical models, one can predict the kinetic profile of drugs and their metabolites and, consequently, develop preventive procedures regarding drug transmission (i.e., determination of appropriate withdrawal periods). Nevertheless, in the present chapter the mathematical and statistical concepts for data interpretation are strictly given to allow understanding of some basic pharma-cokinetic principles and to illustrate the determination of withdrawal periods


Animal Product Clinical Pharmacokinetic Elimination Rate Constant Maximum Residue Limit Veterinary Drug 
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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Amílcar C. Falcão
    • 1
  1. 1.Faculty of PharmacyUniversity of CoimbraCoimbraPortugal

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