Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity

  • Cheryl L. Thompson
  • David Van Vactor
Part of the Molecular Biology Intelligence Unit book series (MBIU)


The nervous system is an organ of immense complexity. Neural function and the integration of neural input depend upon the formation of an intricate network of synaptic connections. Building this neural architecture during development involves several aspects of neuronal morphogenesis, from neuronal polarization and the extension of neuronal processes, to the pathfinding of axons across long distances to appropriate target cells and the elaboration of dendritic arbors, resulting in the assembly and maintenance of synapses between each neuron and its targets. Each neuronal subclass relies upon multiple extracellular cues to direct its pathfinding and synaptogenesis to the correct locations within the developing embryo. While much progress has been made in the identification of the extracellular factors and corresponding cell surface receptors that control these aspects of neuronal differentiation, much less is known about the intracellular molecules and signaling pathways that control the process of morphogenesis.1


Growth Cone Axon Guidance Motor Axon Embryonic Central Nervous System Central Nervous System Axon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Cheryl L. Thompson
    • 1
  • David Van Vactor
    • 1
  1. 1.Department of Cell Biology, Program in Neuroscience, and Harvard Center for Neurodegeneration and RepairHarvard Medical SchoolBostonUSA

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