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Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity

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Abl Family Kinases in Development and Disease

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

The nervous system is an organ of immense complexity. Neural function and the integration of neural input depend upon the formation of an intricate network of synaptic connections. Building this neural architecture during development involves several aspects of neuronal morphogenesis, from neuronal polarization and the extension of neuronal processes, to the pathfinding of axons across long distances to appropriate target cells and the elaboration of dendritic arbors, resulting in the assembly and maintenance of synapses between each neuron and its targets. Each neuronal subclass relies upon multiple extracellular cues to direct its pathfinding and synaptogenesis to the correct locations within the developing embryo. While much progress has been made in the identification of the extracellular factors and corresponding cell surface receptors that control these aspects of neuronal differentiation, much less is known about the intracellular molecules and signaling pathways that control the process of morphogenesis.1

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  1. Department of Cell Biology, Program in Neuroscience, and Harvard Center for Neurodegeneration and Repair, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Cheryl L. Thompson & David Van Vactor

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  2. David Van Vactor
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Thompson, C.L., Van Vactor, D. (2006). Abelson Family Protein Tyrosine Kinases and the Formation of Neuronal Connectivity. In: Abl Family Kinases in Development and Disease. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68744-5_9

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