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Abl Family Kinases in Mammalian Development

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Abl Family Kinases in Development and Disease

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Abl and Arg nonreceptor tyrosine kinases are widely expressed in mammals, where they contribute to the development of diverse organ and tissue systems. Deletion of abl or arg in mice reveals roles for the kinases in B and T lymphocyte development, neurulation, neuronal dendrite maintenance, synaptic plasticity, and osteoblast development. Double knockout abl -/- arg -/- mice die as embryos, indicating that Abl and Arg also perform essential and overlapping functions during embryonic development. Abl and Arg contain domains for protein-protein interactions (SH3, SH2, proline-rich sequences, PY sequences), cytoskeleton binding (filamentous actin and microtubule binding domains), nuclear translocation (nuclear localization and export sequences), and DNA binding. Although a full understanding of their molecular interactions is still forthcoming, it is clear that Abl and Arg provide many cell types with all-in-one multifunctional signaling tools that serve as links between the cell surface and downstream pathways to both the cytoskeleton and nucleus.

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  1. Department of Molecular Biophysics and Biochemistry, Yale Uniersity School of Medicine, New Haven, Connecticut, 06520, USA

    Eva Marie Y. Moresco

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© 2006 Landes Bioscience and Springer Science+Business Media

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Moresco, E.M.Y. (2006). Abl Family Kinases in Mammalian Development. In: Abl Family Kinases in Development and Disease. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68744-5_8

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