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Regulation of Cell Motility by Abl Family Kinases

  • Shahin Emami
  • Richard L. Klemke
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Cell migration is a highly dynamic process that involves regulation of actin-mediated protrusion of a leading lamellipodia and its adhesion to the extracellular matrix, followed by translocation of the cell body and tail retraction at the rear. The migration machinery is regulated in a highly temporal and spatial manner through sophisticated sensing mechanisms that interpret external gradients of chemokines and adhesive proteins present in the extracellular environment. These directional cues are transmitted to the interior of the cell where they couple to the cytoskeletal network. In the following section, we highlight the role of the Abl family of nonreceptor tyrosine kinases, which transmit signals from growth factor and adhesion receptors to the actin and microtubule cytoskeleton of motile cells. These recent findings suggest that Abl kinases may contribute to cell migration processes, including development, wound healing, and immune function, as well as pathological conditions associated with cancer metastasis and inflammation.

Keywords

Cell Migration Hepatocyte Growth Factor Thyroid Cancer Cell Regulate Cell Migration Integrin Ligation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Shahin Emami
    • 1
  • Richard L. Klemke
    • 2
  1. 1.INSERM U482Saint-Antoine HospitalParisFrance
  2. 2.Department of ImmunologyThe Scripps Research InstituteLa JollaUSA

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