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Regulation of Cell Adhesion Responses by Abl Family Kinases

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Abl Family Kinases in Development and Disease

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

Integrins are cell surface receptors that mediate the interactions of cells with each other and the extracellular matrix. In this chapter, we review experiments indicating that the Abl family of nonreceptor tyrosine kinases, Abl and Arg in vertebrates, are important mediators of cellular responses to integrin engagement. During the early stages of cell spreading, integrins trigger the activation of Abl family kinases and their association with multiple focal adhesion proteins. These events lead to phosphorylation of several cytoskeletal regulatory proteins and changes in cell morphology and motility. Integrins may also utilize Abl family kinases to regulate nuclear processes such as gene expression, cell cycle progression and cell survival. Defects in the proper modulation of cell adhesive responses by Abl family kinases are thought to contribute to the progression of chronic myelogenous leukemia and could potentially underlie other human diseases and behavioral disorders.

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  1. Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, 34 Park Street, New Haven, Connecticut, 06508, USA

    Keith Quincy Tanis

  2. Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA

    Martin Alexander Schwartz

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  1. Keith Quincy Tanis
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  2. Martin Alexander Schwartz
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Tanis, K.Q., Schwartz, M.A. (2006). Regulation of Cell Adhesion Responses by Abl Family Kinases. In: Abl Family Kinases in Development and Disease. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68744-5_3

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