Abstract
Constitutive activation of the Abl nonreceptor tyrosine kinases can occur as a result of structural alterations of the Abl1 and Abl2 genes, which leads to the development of leukemia. Tight control of the activities of the endogenous Abl kinases is critical for normal development and maintenance of normal homeostasis. Recent work has revealed that the Abl kinases are activated by diverse cell surface receptors, and function to couple the activated receptors to signaling pathways such as those important for the regulation of cytoskeletal dynamics.
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© 2006 Landes Bioscience and Springer Science+Business Media
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Pendergast, A.M. (2006). Role of Abl Family Kinases in Growth Factor-Mediated Signaling. In: Abl Family Kinases in Development and Disease. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68744-5_2
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DOI: https://doi.org/10.1007/978-0-387-68744-5_2
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-36640-1
Online ISBN: 978-0-387-68744-5
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