Role of Abl Family Kinases in Growth Factor-Mediated Signaling

  • Ann Marie Pendergast
Part of the Molecular Biology Intelligence Unit book series (MBIU)


Constitutive activation of the Abl nonreceptor tyrosine kinases can occur as a result of structural alterations of the Abl1 and Abl2 genes, which leads to the development of leukemia. Tight control of the activities of the endogenous Abl kinases is critical for normal development and maintenance of normal homeostasis. Recent work has revealed that the Abl kinases are activated by diverse cell surface receptors, and function to couple the activated receptors to signaling pathways such as those important for the regulation of cytoskeletal dynamics.


Netrin Receptor Enhance Tyrosine Phosphorylation Inositol Bisphosphate Zap70 Tyrosine Kinase Phosphatidyl Inositol Bisphosphate 
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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  • Ann Marie Pendergast
    • 1
  1. 1.Department of Pharmacology and Cancer BiologyDuke University Medical CenterDurhamUSA

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