Control versus CTL-Induced Pathology

Part of the Interdisciplinary Applied Mathematics book series (IAM, volume 32)


A major mechanism by which CTL fight viruses is the lysis or killing of infected cells. This removes the source of virus production and contributes to virus clearance. As discussed in Chapter 8, lysis of infected cells can be essential for the resolution of infection [(1999); (1996); (1995b); (1998); (1999)]. This form of antiviral activity can, however, also have a negative impact on the host [(1971); (1993c); (1996)]. If many cells are infected, then lysis of these cells can lead to a significant amount of tissue damage. This can result in pathology, and even in the death of the host. Such damage, brought about by CTL responses that fight an infection, is referred to as CTL-induced pathology.


Virus Load Infected Cell Viral Replication Replication Rate High Virus Load 
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© Springer Science+Business Media, LLC 2007

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