Overview of Vaccine Effects and Study Designs
We focus on the relation between the vaccine effects of interest and the choice of comparison groups, the unit of observation, the choice of parameter, and the amount of information about the transmission system required for estimation. The frame-work draws on the dependent happening relation in infectious diseases. Although the framework is not exhaustive, many designs not considered explicitly in this overview are special cases of these general designs. Our primary concern in this chapter is conceptual. Details of study design and methods of estimation and inference are left to following chapters.
KeywordsHazard Rate Cumulative Incidence Attack Rate Transmission Probability Contact Rate
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