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Overview of Vaccine Effects and Study Designs

  • M. Elizabeth Halloran
  • Ira M. LonginiJr.
  • Claudio J. Struchiner
Chapter
Part of the Statistics for Biology and Health book series (SBH)

Abstract

In this chapter, we present a systematic framework showing the relation among many of the different vaccination effects and the parameters and study designs to estimate them. This framework provides a structure for thinking about the different vaccine effects of interest and how they are related to one another. We present different versions of vaccine efficacy and effectiveness as one minus some measure of relative risk, RR.
$$VE = 1 - RR.$$

We focus on the relation between the vaccine effects of interest and the choice of comparison groups, the unit of observation, the choice of parameter, and the amount of information about the transmission system required for estimation. The frame-work draws on the dependent happening relation in infectious diseases. Although the framework is not exhaustive, many designs not considered explicitly in this overview are special cases of these general designs. Our primary concern in this chapter is conceptual. Details of study design and methods of estimation and inference are left to following chapters.

Keywords

Hazard Rate Cumulative Incidence Attack Rate Transmission Probability Contact Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York 2010

Authors and Affiliations

  • M. Elizabeth Halloran
    • 1
  • Ira M. LonginiJr.
    • 1
  • Claudio J. Struchiner
    • 2
  1. 1.Center for Statistics and Quantitative Infectious DiseasesUniversity of Washington, and Fred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Escola Nacional de Saúde Pública Fundação Oswaldo CruzRio de JaneiroBrazil

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